1b0u
From Proteopedia
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| - | [[Image:1b0u.jpg|left|200px]] | + | [[Image:1b0u.jpg|left|200px]] |
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| - | '''ATP-BINDING SUBUNIT OF THE HISTIDINE PERMEASE FROM SALMONELLA TYPHIMURIUM''' | + | {{Structure |
| + | |PDB= 1b0u |SIZE=350|CAPTION= <scene name='initialview01'>1b0u</scene>, resolution 1.50Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=ATP:ADENOSINE-5'-TRIPHOSPHATE'>ATP</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''ATP-BINDING SUBUNIT OF THE HISTIDINE PERMEASE FROM SALMONELLA TYPHIMURIUM''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1B0U is a [ | + | 1B0U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0U OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the ATP-binding subunit of an ABC transporter., Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF, Kim SH, Nature. 1998 Dec 17;396(6712):703-7. PMID:[http:// | + | Crystal structure of the ATP-binding subunit of an ABC transporter., Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF, Kim SH, Nature. 1998 Dec 17;396(6712):703-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9872322 9872322] |
[[Category: Salmonella typhimurium]] | [[Category: Salmonella typhimurium]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transport protein]] | [[Category: transport protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:04:49 2008'' |
Revision as of 08:04, 20 March 2008
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| , resolution 1.50Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
ATP-BINDING SUBUNIT OF THE HISTIDINE PERMEASE FROM SALMONELLA TYPHIMURIUM
Overview
ABC transporters (also known as traffic ATPases) form a large family of proteins responsible for the translocation of a variety of compounds across membranes of both prokaryotes and eukaryotes. The recently completed Escherichia coli genome sequence revealed that the largest family of paralogous E. coli proteins is composed of ABC transporters. Many eukaryotic proteins of medical significance belong to this family, such as the cystic fibrosis transmembrane conductance regulator (CFTR), the P-glycoprotein (or multidrug-resistance protein) and the heterodimeric transporter associated with antigen processing (Tap1-Tap2). Here we report the crystal structure at 1.5 A resolution of HisP, the ATP-binding subunit of the histidine permease, which is an ABC transporter from Salmonella typhimurium. We correlate the details of this structure with the biochemical, genetic and biophysical properties of the wild-type and several mutant HisP proteins. The structure provides a basis for understanding properties of ABC transporters and of defective CFTR proteins.
About this Structure
1B0U is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.
Reference
Crystal structure of the ATP-binding subunit of an ABC transporter., Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF, Kim SH, Nature. 1998 Dec 17;396(6712):703-7. PMID:9872322
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