3t79

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[[Image:3t79.png|left|200px]]
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==Ndc10: a platform for inner kinetochore assembly in budding yeast==
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<StructureSection load='3t79' size='340' side='right' caption='[[3t79]], [[Resolution|resolution]] 3.61&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3t79]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T79 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sqi|3sqi]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLLA0E03807g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 Kluyveromyces lactis])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t79 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t79 RCSB], [http://www.ebi.ac.uk/pdbsum/3t79 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Kinetochores link centromeric DNA to spindle microtubules and ensure faithful chromosome segregation during mitosis. In point-centromere yeasts, the CBF3 complex Skp1-Ctf13-(Cep3)(2)-(Ndc10)(2) recognizes a conserved centromeric DNA element through contacts made by Cep3 and Ndc10. We describe here the five-domain organization of Kluyveromyces lactis Ndc10 and the structure at 2.8 A resolution of domains I-II (residues 1-402) bound to DNA. The structure resembles tyrosine DNA recombinases, although it lacks both endonuclease and ligase activities. Structural and biochemical data demonstrate that each subunit of the Ndc10 dimer binds a separate fragment of DNA, suggesting that Ndc10 stabilizes a DNA loop at the centromere. We describe in vitro association experiments showing that specific domains of Ndc10 interact with each of the known inner-kinetochore proteins or protein complexes in budding yeast. We propose that Ndc10 provides a central platform for inner-kinetochore assembly.
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Ndc10 is a platform for inner kinetochore assembly in budding yeast.,Cho US, Harrison SC Nat Struct Mol Biol. 2011 Dec 4. doi: 10.1038/nsmb.2178. PMID:22139014<ref>PMID:22139014</ref>
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The line below this paragraph, containing "STRUCTURE_3t79", creates the "Structure Box" on the page.
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{{STRUCTURE_3t79| PDB=3t79 | SCENE= }}
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===Ndc10: a platform for inner kinetochore assembly in budding yeast===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22139014}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22139014 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22139014}}
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==About this Structure==
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[[3t79]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T79 OCA].
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==Reference==
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<ref group="xtra">PMID:022139014</ref><references group="xtra"/>
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[[Category: Kluyveromyces lactis]]
[[Category: Kluyveromyces lactis]]
[[Category: Cho, U S.]]
[[Category: Cho, U S.]]

Revision as of 06:10, 5 June 2014

Ndc10: a platform for inner kinetochore assembly in budding yeast

3t79, resolution 3.61Å

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