3uzv

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[[Image:3uzv.png|left|200px]]
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==Crystal structure of the dengue virus serotype 2 envelope protein domain III in complex with the variable domains of Mab 4E11==
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<StructureSection load='3uzv' size='340' side='right' caption='[[3uzv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3uzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UZV FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EOH:ETHANOL'>EOH</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uzq|3uzq]], [[3uyp|3uyp]], [[3uze|3uze]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uzv RCSB], [http://www.ebi.ac.uk/pdbsum/3uzv PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The dengue virus (DENV) complex is composed of four distinct but serologically related flaviviruses, which together cause the present-day most important emerging viral disease. Although DENV infection induces lifelong immunity against viruses of the same serotype, the antibodies raised appear to contribute to severe disease in cases of heterotypic infections. Understanding the mechanisms of DENV neutralization by antibodies is, therefore, crucial for the design of vaccines that simultaneously protect against all four viruses. Here, we report a comparative, high-resolution crystallographic analysis of an "A-strand" murine monoclonal antibody, Mab 4E11, in complex with its target domain of the envelope protein from the four DENVs. Mab 4E11 is capable of neutralizing all four serotypes, and our study reveals the determinants of this cross-reactivity. The structures also highlight the mechanism by which A-strand Mabs disrupt the architecture of the mature virion, inducing premature fusion loop exposure and concomitant particle inactivation.
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Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody.,Cockburn JJ, Navarro Sanchez ME, Fretes N, Urvoas A, Staropoli I, Kikuti CM, Coffey LL, Arenzana Seisdedos F, Bedouelle H, Rey FA Structure. 2012 Feb 8;20(2):303-14. Epub 2012 Jan 26. PMID:22285214<ref>PMID:22285214</ref>
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The line below this paragraph, containing "STRUCTURE_3uzv", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3uzv| PDB=3uzv | SCENE= }}
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===Crystal structure of the dengue virus serotype 2 envelope protein domain III in complex with the variable domains of Mab 4E11===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22285214}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22285214 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22285214}}
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==About this Structure==
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[[3uzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UZV OCA].
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==Reference==
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<ref group="xtra">PMID:022285214</ref><references group="xtra"/>
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[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]

Revision as of 06:14, 5 June 2014

Crystal structure of the dengue virus serotype 2 envelope protein domain III in complex with the variable domains of Mab 4E11

3uzv, resolution 2.10Å

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