1b34
From Proteopedia
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| - | [[Image:1b34.gif|left|200px]] | + | [[Image:1b34.gif|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN''' | + | {{Structure |
| + | |PDB= 1b34 |SIZE=350|CAPTION= <scene name='initialview01'>1b34</scene>, resolution 2.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1B34 is a [ | + | 1B34 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B34 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs., Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K, Cell. 1999 Feb 5;96(3):375-87. PMID:[http:// | + | Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs., Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K, Cell. 1999 Feb 5;96(3):375-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10025403 10025403] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: systemic lupus erythematosus]] | [[Category: systemic lupus erythematosus]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:05:36 2008'' |
Revision as of 08:05, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN
Overview
The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F, and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs (snRNAs). These proteins share a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. Crystal structures of two Sm protein complexes, D3B and D1D2, show that these proteins have a common fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta sheet, and the D1D2 and D3B dimers superpose closely in their core regions, including the dimer interfaces. The crystal structures suggest that the seven Sm proteins could form a closed ring and the snRNAs may be bound in the positively charged central hole.
About this Structure
1B34 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs., Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K, Cell. 1999 Feb 5;96(3):375-87. PMID:10025403
Page seeded by OCA on Thu Mar 20 10:05:36 2008
Categories: Homo sapiens | Protein complex | Avis, J M. | Fortelle, E De La. | Kambach, C. | Li, J. | Nagai, K. | Walke, S. | Young, R J. | Core snrnp domain | Sle | Sm | Snrnp | Spliceosome | Splicing | Systemic lupus erythematosus
