3th9

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[[Image:3th9.png|left|200px]]
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==Crystal Structure of HIV-1 Protease Mutant Q7K V32I L63I with a cyclic sulfonamide inhibitor==
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<StructureSection load='3th9' size='340' side='right' caption='[[3th9]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3th9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_lw12.3_isolate Human immunodeficiency virus type 1 lw12.3 isolate]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TH9 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9Y9:TERT-BUTYL+{(2S,3R)-4-[(4S)-7-FLUORO-4-METHYL-1,1-DIOXIDO-4,5-DIHYDRO-1,2-BENZOTHIAZEPIN-2(3H)-YL]-3-HYDROXY-1-PHENYLBUTAN-2-YL}CARBAMATE'>9Y9</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=82834 Human immunodeficiency virus type 1 lw12.3 isolate])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3th9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3th9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3th9 RCSB], [http://www.ebi.ac.uk/pdbsum/3th9 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Abstract In the present paper, design, synthesis, X-ray crystallographic analysis and HIV-1 protease inhibitory activities of a novel class of compounds are disclosed. Compounds 28-30, 32, 35, and 40 were synthesized and found to be inhibitors of the HIV-1 protease. The crucial step in their synthesis involved an unusual endo radical cyclization process. Absolute stereochemistry of the three asymmetric centers in the above compounds have been established to be (4S,2'R,3'S) for optimal potency. X-ray crystallographic analysis has been used to determine the binding mode of the inhibitors to the HIV-1 protease.
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Design, Synthesis and X-ray crystallographic analysis of a Novel Class of HIV-1 Protease Inhibitors.,Ganguly AK, Alluri SS, Caroccia D, Biswas D, Wang CH, Kang E, Zhang Y, McPhail AT, Carroll SS, Burlein C, Munshi V, Orth P, Strickland C J Med Chem. 2011 Sep 14. PMID:21916489<ref>PMID:21916489</ref>
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The line below this paragraph, containing "STRUCTURE_3th9", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3th9| PDB=3th9 | SCENE= }}
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===Crystal Structure of HIV-1 Protease Mutant Q7K V32I L63I with a cyclic sulfonamide inhibitor===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21916489}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21916489 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21916489}}
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==About this Structure==
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[[3th9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_lw12.3_isolate Human immunodeficiency virus type 1 lw12.3 isolate]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TH9 OCA].
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==Reference==
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<ref group="xtra">PMID:021916489</ref><references group="xtra"/>
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[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus type 1 lw12 3 isolate]]
[[Category: Human immunodeficiency virus type 1 lw12 3 isolate]]

Revision as of 06:38, 5 June 2014

Crystal Structure of HIV-1 Protease Mutant Q7K V32I L63I with a cyclic sulfonamide inhibitor

3th9, resolution 1.34Å

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