3tw4

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[[Image:3tw4.png|left|200px]]
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==Crystal Structure of Human Septin 7 GTPase Domain==
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<StructureSection load='3tw4' size='340' side='right' caption='[[3tw4]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tw4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TW4 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SEPT7, CDC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tw4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tw4 RCSB], [http://www.ebi.ac.uk/pdbsum/3tw4 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We describe the purification, crystallization and structure for the GTP-binding domain of human septin 7 (SEPT7G). We show that it forms filaments within the crystal lattice which employ both the G and NC interfaces, similar to those seen in the hetero-filament of SEPT2/6/7. The NC interface is considered promiscuous as it is absent from the hetero-filament. Such promiscuity could provide the potential for permuting monomers along a filament in order to generate diversity in hetero-polymers. On the other hand, our results suggest that the G and NC interfaces may be necessary but insufficient for determining correct hetero-filament assembly. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: SEPT7G and SEPT7Gbind by X-ray crystallography (View interaction). SEPT7 G and SEPT7 Gbind by molecular sieving (View interaction).
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Promiscuous interactions of human septins: The GTP binding domain of SEPT7 forms filaments within the crystal.,Serrao VH, Alessandro F, Caldas VE, Marcal RL, D'Muniz Pereira H, Thiemann OH, Garratt RC FEBS Lett. 2011 Nov 3. PMID:22064074<ref>PMID:22064074</ref>
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The line below this paragraph, containing "STRUCTURE_3tw4", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3tw4| PDB=3tw4 | SCENE= }}
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===Crystal Structure of Human Septin 7 GTPase Domain===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22064074}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22064074 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22064074}}
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==About this Structure==
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[[3tw4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TW4 OCA].
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==Reference==
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<ref group="xtra">PMID:022064074</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Alessandro, F.]]
[[Category: Alessandro, F.]]

Revision as of 06:43, 5 June 2014

Crystal Structure of Human Septin 7 GTPase Domain

3tw4, resolution 3.35Å

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