1b5s

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[[Image:1b5s.jpg|left|200px]]<br /><applet load="1b5s" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1b5s.jpg|left|200px]]
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caption="1b5s, resolution 4.4&Aring;" />
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'''DIHYDROLIPOYL TRANSACETYLASE (E.C.2.3.1.12) CATALYTIC DOMAIN (RESIDUES 184-425) FROM BACILLUS STEAROTHERMOPHILUS'''<br />
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{{Structure
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|PDB= 1b5s |SIZE=350|CAPTION= <scene name='initialview01'>1b5s</scene>, resolution 4.4&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12]
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|GENE=
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}}
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'''DIHYDROLIPOYL TRANSACETYLASE (E.C.2.3.1.12) CATALYTIC DOMAIN (RESIDUES 184-425) FROM BACILLUS STEAROTHERMOPHILUS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1B5S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Active as [http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B5S OCA].
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1B5S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B5S OCA].
==Reference==
==Reference==
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Principles of quasi-equivalence and Euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes., Izard T, Aevarsson A, Allen MD, Westphal AH, Perham RN, de Kok A, Hol WG, Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1240-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9990008 9990008]
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Principles of quasi-equivalence and Euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes., Izard T, Aevarsson A, Allen MD, Westphal AH, Perham RN, de Kok A, Hol WG, Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1240-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9990008 9990008]
[[Category: Dihydrolipoyllysine-residue acetyltransferase]]
[[Category: Dihydrolipoyllysine-residue acetyltransferase]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: pyruvate dehydrogenase]]
[[Category: pyruvate dehydrogenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:51:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:06:40 2008''

Revision as of 08:06, 20 March 2008

Image:1b5s.jpg


PDB ID 1b5s

Drag the structure with the mouse to rotate
, resolution 4.4Å
Activity: Dihydrolipoyllysine-residue acetyltransferase, with EC number 2.3.1.12
Coordinates: save as pdb, mmCIF, xml



DIHYDROLIPOYL TRANSACETYLASE (E.C.2.3.1.12) CATALYTIC DOMAIN (RESIDUES 184-425) FROM BACILLUS STEAROTHERMOPHILUS


Overview

The pyruvate dehydrogenase multienzyme complex (Mr of 5-10 million) is assembled around a structural core formed of multiple copies of dihydrolipoyl acetyltransferase (E2p), which exhibits the shape of either a cube or a dodecahedron, depending on the source. The crystal structures of the 60-meric dihydrolipoyl acyltransferase cores of Bacillus stearothermophilus and Enterococcus faecalis pyruvate dehydrogenase complexes were determined and revealed a remarkably hollow dodecahedron with an outer diameter of approximately 237 A, 12 large openings of approximately 52 A diameter across the fivefold axes, and an inner cavity with a diameter of approximately 118 A. Comparison of cubic and dodecahedral E2p assemblies shows that combining the principles of quasi-equivalence formulated by Caspar and Klug [Caspar, D. L. & Klug, A. (1962) Cold Spring Harbor Symp. Quant. Biol. 27, 1-4] with strict Euclidean geometric considerations results in predictions of the major features of the E2p dodecahedron matching the observed features almost exactly.

About this Structure

1B5S is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Principles of quasi-equivalence and Euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes., Izard T, Aevarsson A, Allen MD, Westphal AH, Perham RN, de Kok A, Hol WG, Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1240-5. PMID:9990008

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