3zx1

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[[Image:3zx1.png|left|200px]]
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==Multicopper oxidase from Campylobacter jejuni: a metallo-oxidase==
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<StructureSection load='3zx1' size='340' side='right' caption='[[3zx1]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zx1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni Campylobacter jejuni subsp. jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZX1 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zx1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zx1 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Multicopper oxidases are a multi-domain family of enzymes that are able to couple oxidation of substrates with reduction of dioxygen to water. These enzymes are capable of oxidizing a vast range of substrates, varying from aromatic to inorganic compounds such as metals. This metallo-oxidase activity observed in several members of this family has been linked to mechanisms of homeostasis in different organisms. Recently, a periplasmic multicopper oxidase, encoded by Campylobacter jejuni, has been characterised and associated with copper homeostasis and with the protection against oxidative stress as it may scavenge metallic ions into their less toxic form and also inhibit the formation of radical oxygen species. In order to contribute to the understanding of its functional role, the crystal structure of the recombinant McoC (Campylobacter jejuni CGUG11284) has been determined at 1.95 A resolution and its structural and biochemical characterizations undertaken. The results obtained indicate that McoC has the characteristic fold of a laccase having, besides the catalytic centres, another putative binding site for metals. Indeed, its biochemical and enzymatic characterization shows that McoC is essentially a metallo-oxidase, showing low enzymatic efficiency towards phenolic substrates.
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Crystal structure of the multicopper oxidase from the pathogenic bacterium Campylobacter jejuni CGUG11284: characterization of a metallo-oxidase.,Silva CS, Durao P, Fillat A, Lindley PF, Martins LO, Bento I Metallomics. 2011 Nov 29. PMID:22127520<ref>PMID:22127520</ref>
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The line below this paragraph, containing "STRUCTURE_3zx1", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3zx1| PDB=3zx1 | SCENE= }}
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===Multicopper oxidase from Campylobacter jejuni: a metallo-oxidase===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22127520}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22127520 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22127520}}
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==About this Structure==
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[[3zx1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni Campylobacter jejuni subsp. jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX1 OCA].
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==Reference==
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<ref group="xtra">PMID:022127520</ref><references group="xtra"/>
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[[Category: Campylobacter jejuni subsp. jejuni]]
[[Category: Campylobacter jejuni subsp. jejuni]]
[[Category: Bento, I.]]
[[Category: Bento, I.]]

Revision as of 07:19, 5 June 2014

Multicopper oxidase from Campylobacter jejuni: a metallo-oxidase

3zx1, resolution 1.95Å

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