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3vdj

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[[Image:3vdj.png|left|200px]]
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==Crystal structure of circumsporozoite protein aTSR domain, R32 native form==
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<StructureSection load='3vdj' size='340' side='right' caption='[[3vdj]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3vdj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VDJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VDJ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vdk|3vdk]], [[3vdl|3vdl]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PFC0210c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vdj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vdj RCSB], [http://www.ebi.ac.uk/pdbsum/3vdj PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Circumsporozoite (CS) protein is the major surface component of Plasmodium falciparum sporozoites and is essential for host cell invasion. A vaccine containing tandem repeats, region III, and thrombospondin type-I repeat (TSR) of CS is efficacious in phase III trials but gives only a 35% reduction in severe malaria in the first year postimmunization. We solved crystal structures showing that region III and TSR fold into a single unit, an "alphaTSR" domain. The alphaTSR domain possesses a hydrophobic pocket and core, missing in TSR domains. CS binds heparin, but alphaTSR does not. Interestingly, polymorphic T-cell epitopes map to specialized alphaTSR regions. The N and C termini are unexpectedly close, providing clues for sporozoite sheath organization. Elucidation of a unique structure of a domain within CS enables rational design of next-generation subunit vaccines and functional and medicinal chemical investigation of the conserved hydrophobic pocket.
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Unexpected fold in the circumsporozoite protein target of malaria vaccines.,Doud MB, Koksal AC, Mi LZ, Song G, Lu C, Springer TA Proc Natl Acad Sci U S A. 2012 Apr 30. PMID:22547819<ref>PMID:22547819</ref>
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The line below this paragraph, containing "STRUCTURE_3vdj", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3vdj| PDB=3vdj | SCENE= }}
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===Crystal structure of circumsporozoite protein aTSR domain, R32 native form===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22547819}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22547819 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22547819}}
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==About this Structure==
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[[3vdj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VDJ OCA].
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==Reference==
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<ref group="xtra">PMID:022547819</ref><references group="xtra"/>
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[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
[[Category: Doud, M B.]]
[[Category: Doud, M B.]]

Revision as of 07:20, 5 June 2014

Crystal structure of circumsporozoite protein aTSR domain, R32 native form

3vdj, resolution 1.70Å

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