1b7f

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[[Image:1b7f.gif|left|200px]]<br /><applet load="1b7f" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1b7f.gif|left|200px]]
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caption="1b7f, resolution 2.6&Aring;" />
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'''SXL-LETHAL PROTEIN/RNA COMPLEX'''<br />
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{{Structure
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|PDB= 1b7f |SIZE=350|CAPTION= <scene name='initialview01'>1b7f</scene>, resolution 2.6&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''SXL-LETHAL PROTEIN/RNA COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1B7F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B7F OCA].
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1B7F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B7F OCA].
==Reference==
==Reference==
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Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein., Handa N, Nureki O, Kurimoto K, Kim I, Sakamoto H, Shimura Y, Muto Y, Yokoyama S, Nature. 1999 Apr 15;398(6728):579-85. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10217141 10217141]
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Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein., Handa N, Nureki O, Kurimoto K, Kim I, Sakamoto H, Shimura Y, Muto Y, Yokoyama S, Nature. 1999 Apr 15;398(6728):579-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10217141 10217141]
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: rsgi]]
[[Category: rsgi]]
[[Category: splicing regulation]]
[[Category: splicing regulation]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:52:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:07:16 2008''

Revision as of 08:07, 20 March 2008

Image:1b7f.gif


PDB ID 1b7f

Drag the structure with the mouse to rotate
, resolution 2.6Å
Coordinates: save as pdb, mmCIF, xml



SXL-LETHAL PROTEIN/RNA COMPLEX


Overview

The Sex-lethal (Sxl) protein of Drosophila melanogaster regulates alternative splicing of the transformer (tra) messenger RNA precursor by binding to the tra polypyrimidine tract during the sex-determination process. The crystal structure has now been determined at 2.6 A resolution of the complex formed between two tandemly arranged RNA-binding domains of the Sxl protein and a 12-nucleotide, single-stranded RNA derived from the tra polypyrimidine tract. The two RNA-binding domains have their beta-sheet platforms facing each other to form a V-shaped cleft. The RNA is characteristically extended and bound in this cleft, where the UGUUUUUUU sequence is specifically recognized by the protein. This structure offers the first insight, to our knowledge, into how a protein binds specifically to a cognate RNA without any intramolecular base-pairing.

About this Structure

1B7F is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein., Handa N, Nureki O, Kurimoto K, Kim I, Sakamoto H, Shimura Y, Muto Y, Yokoyama S, Nature. 1999 Apr 15;398(6728):579-85. PMID:10217141

Page seeded by OCA on Thu Mar 20 10:07:16 2008

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