407d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "407d" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:407d.png|left|200px]]
+
==STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA==
 +
<StructureSection load='407d' size='340' side='right' caption='[[407d]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[407d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=407D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=407D FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HP1:IMIDAZOLE-PYRROLE-HYDROXYPYRROLE+POLYAMIDE'>HP1</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=407d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=407d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=407d RCSB], [http://www.ebi.ac.uk/pdbsum/407d PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Polyamide dimers containing three types of aromatic rings-pyrrole, imidazole, and hydroxypyrrole-afford a small-molecule recognition code that discriminates among all four Watson-Crick base pairs in the minor groove. The crystal structure of a specific polyamide dimer-DNA complex establishes the structural basis for distinguishing T.A from A.T base pairs. Specificity for the T.A base pair is achieved by means of distinct hydrogen bonds between pairs of substituted pyrroles on the ligand and the O2 of thymine and N3 of adenine. In addition, shape-selective recognition of an asymmetric cleft between the thymine-O2 and the adenine-C2 was observed. Although hitherto similarities among the base pairs in the minor groove have been emphasized, the structure illustrates differences that allow specific minor groove recognition.
-
<!--
+
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA.,Kielkopf CL, White S, Szewczyk JW, Turner JM, Baird EE, Dervan PB, Rees DC Science. 1998 Oct 2;282(5386):111-5. PMID:9756473<ref>PMID:9756473</ref>
-
The line below this paragraph, containing "STRUCTURE_407d", creates the "Structure Box" on the page.
+
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
-
or leave the SCENE parameter empty for the default display.
+
-
-->
+
-
{{STRUCTURE_407d| PDB=407d | SCENE= }}
+
-
===STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA===
+
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_9756473}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 9756473 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_9756473}}
+
-
 
+
-
==About this Structure==
+
-
[[407d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=407D OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:009756473</ref><references group="xtra"/>
+
[[Category: Rees]]
[[Category: Rees]]
[[Category: Dna]]
[[Category: Dna]]
[[Category: Drugs in the dna minor groove]]
[[Category: Drugs in the dna minor groove]]

Revision as of 07:26, 5 June 2014

STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA

407d, resolution 2.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/407d"
Views
Personal tools
Navigation
Toolbox