1b86

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[[Image:1b86.gif|left|200px]]<br /><applet load="1b86" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1b86.gif|left|200px]]
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caption="1b86, resolution 2.5&Aring;" />
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'''HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX'''<br />
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{{Structure
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|PDB= 1b86 |SIZE=350|CAPTION= <scene name='initialview01'>1b86</scene>, resolution 2.5&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=DDH:[7,12-DEACETYL-3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPANOATO(2-)-N21,N22,N23,N24]-IRON'>DDH</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=DG2:2,3-DIPHOSPHOGLYCERIC ACID'>DG2</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1B86 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=DDH:'>DDH</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=DG2:'>DG2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B86 OCA].
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1B86 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B86 OCA].
==Reference==
==Reference==
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Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt structure at 2.5 A resolution., Richard V, Dodson GG, Mauguen Y, J Mol Biol. 1993 Sep 20;233(2):270-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8377203 8377203]
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Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt structure at 2.5 A resolution., Richard V, Dodson GG, Mauguen Y, J Mol Biol. 1993 Sep 20;233(2):270-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8377203 8377203]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: haemoglobin]]
[[Category: haemoglobin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:52:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:07:32 2008''

Revision as of 08:07, 20 March 2008

Image:1b86.gif


PDB ID 1b86

Drag the structure with the mouse to rotate
, resolution 2.5Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX


Contents

Overview

The haemoglobin-2,3-diphosphoglycerate complex structure has been solved at 2.5 A resolution using crystals grown from low-salt solutions. The results show some important differences with the precedent haemoglobin-2,3-diphosphoglycerate high-salt structure solved by Arnone. First, we observe a loss of symmetry in the binding site, secondly both of the lysine residues 82 beta interact with 2,3-diphosphoglycerate at the same time, each making two contacts. This level of interaction is in agreement with the functional behaviour of natural haemoglobin mutants with mutations at the 2,3-diphosphoglycerate binding site.

Disease

Known diseases associated with this structure: Erythremias, alpha- OMIM:[141800], Erythremias, beta- OMIM:[141900], Erythrocytosis OMIM:[141850], HPFH, deletion type OMIM:[141900], Heinz body anemia OMIM:[141850], Heinz body anemias, alpha- OMIM:[141800], Heinz body anemias, beta- OMIM:[141900], Hemoglobin H disease OMIM:[141850], Hypochromic microcytic anemia OMIM:[141850], Methemoglobinemias, alpha- OMIM:[141800], Methemoglobinemias, beta- OMIM:[141900], Sickle cell anemia OMIM:[141900], Thalassemia, alpha- OMIM:[141850], Thalassemia-beta, dominant inclusion-body OMIM:[141900], Thalassemias, alpha- OMIM:[141800], Thalassemias, beta- OMIM:[141900]

About this Structure

1B86 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt structure at 2.5 A resolution., Richard V, Dodson GG, Mauguen Y, J Mol Biol. 1993 Sep 20;233(2):270-4. PMID:8377203

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