4er6
From Proteopedia
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| - | [[ | + | ==Crystal structure of human DOT1L in complex with inhibitor SGC0946== |
| + | <StructureSection load='4er6' size='340' side='right' caption='[[4er6]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4er6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ER6 FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AW2:5-BROMO-7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>AW2</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eqz|4eqz]], [[4er0|4er0]], [[4er3|4er3]], [[4er5|4er5]], [[4er7|4er7]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DOT1L, KIAA1814, KMT4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4er6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4er6 RCSB], [http://www.ebi.ac.uk/pdbsum/4er6 PDBsum]</span></td></tr> | ||
| + | <table> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone methyltransferase|Histone methyltransferase]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | [[ | + | |
[[Category: Histone-lysine N-methyltransferase]] | [[Category: Histone-lysine N-methyltransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 07:29, 5 June 2014
Crystal structure of human DOT1L in complex with inhibitor SGC0946
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Categories: Histone-lysine N-methyltransferase | Homo sapiens | Arrowsmith, C H. | Bountra, C. | Bradner, J E. | Brown, P J. | Edwards, A M. | Li, Y. | Nguyen, K T. | SGC, Structural Genomics Consortium. | Schapira, M. | Scopton, A. | Tempel, W. | Vedadi, M. | Wernimont, A K. | Yu, W. | Epigenetic | Histone | Methyltransferase | Transferase-transferase inhibitor complex
