This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8drh
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==HIGH RESOLUTION NMR STRUCTURE OF THE D(GCGTCAGG)R(CCUGACGC) HYBRID, MINIMIZED AVERAGE STRUCTURE== | |
| - | [[ | + | <StructureSection load='8drh' size='340' side='right' caption='[[8drh]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8drh]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8DRH FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[8psh|8psh]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8drh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8drh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=8drh RCSB], [http://www.ebi.ac.uk/pdbsum/8drh PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | In this work, we present the first NMR solution structure of a DNA/RNA hybrid containing stereoregular Rp-phosphorothioate modifications of all DNA backbone linkages. The complex of the enzymatically synthesized phosphorothioate DNA octamer (all-Rp)-d(GCGTCAGG) and its complementary RNA r(CCUGACGC) was found to adopt an overall conformation within the A-form family. Most helical parameters and the sugar puckers of the DNA strand assume values intermediate between A- and B-form. The close structural similarity with the unmodified DNA/RNA hybrid of the same sequence may explain why both the natural and the sulfur-substituted complex can be recognized and digested by ribonuclease H. | ||
| - | + | Structure of a stereoregular phosphorothioate DNA/RNA duplex.,Bachelin M, Hessler G, Kurz G, Hacia JG, Dervan PB, Kessler H Nat Struct Biol. 1998 Apr;5(4):271-6. PMID:9546216<ref>PMID:9546216</ref> | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | == | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
[[Category: Bachelin, M.]] | [[Category: Bachelin, M.]] | ||
[[Category: Dervan, P B.]] | [[Category: Dervan, P B.]] | ||
| Line 31: | Line 25: | ||
[[Category: Kurz, G.]] | [[Category: Kurz, G.]] | ||
[[Category: Deoxyribonucleic acid/ribonucleic acid]] | [[Category: Deoxyribonucleic acid/ribonucleic acid]] | ||
| + | [[Category: Dna-rna hybrid]] | ||
[[Category: Dna/rna hybrid]] | [[Category: Dna/rna hybrid]] | ||
[[Category: Oligonucleotide]] | [[Category: Oligonucleotide]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 12:56:17 2008'' | ||
Revision as of 07:31, 5 June 2014
HIGH RESOLUTION NMR STRUCTURE OF THE D(GCGTCAGG)R(CCUGACGC) HYBRID, MINIMIZED AVERAGE STRUCTURE
| |||||||||||
