8drh
From Proteopedia
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| - | + | ==HIGH RESOLUTION NMR STRUCTURE OF THE D(GCGTCAGG)R(CCUGACGC) HYBRID, MINIMIZED AVERAGE STRUCTURE== | |
| - | [[ | + | <StructureSection load='8drh' size='340' side='right' caption='[[8drh]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8drh]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8DRH FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[8psh|8psh]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8drh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8drh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=8drh RCSB], [http://www.ebi.ac.uk/pdbsum/8drh PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | In this work, we present the first NMR solution structure of a DNA/RNA hybrid containing stereoregular Rp-phosphorothioate modifications of all DNA backbone linkages. The complex of the enzymatically synthesized phosphorothioate DNA octamer (all-Rp)-d(GCGTCAGG) and its complementary RNA r(CCUGACGC) was found to adopt an overall conformation within the A-form family. Most helical parameters and the sugar puckers of the DNA strand assume values intermediate between A- and B-form. The close structural similarity with the unmodified DNA/RNA hybrid of the same sequence may explain why both the natural and the sulfur-substituted complex can be recognized and digested by ribonuclease H. | ||
| - | + | Structure of a stereoregular phosphorothioate DNA/RNA duplex.,Bachelin M, Hessler G, Kurz G, Hacia JG, Dervan PB, Kessler H Nat Struct Biol. 1998 Apr;5(4):271-6. PMID:9546216<ref>PMID:9546216</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Bachelin, M.]] | [[Category: Bachelin, M.]] | ||
[[Category: Dervan, P B.]] | [[Category: Dervan, P B.]] | ||
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[[Category: Kurz, G.]] | [[Category: Kurz, G.]] | ||
[[Category: Deoxyribonucleic acid/ribonucleic acid]] | [[Category: Deoxyribonucleic acid/ribonucleic acid]] | ||
| + | [[Category: Dna-rna hybrid]] | ||
[[Category: Dna/rna hybrid]] | [[Category: Dna/rna hybrid]] | ||
[[Category: Oligonucleotide]] | [[Category: Oligonucleotide]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 12:56:17 2008'' | ||
Revision as of 07:31, 5 June 2014
HIGH RESOLUTION NMR STRUCTURE OF THE D(GCGTCAGG)R(CCUGACGC) HYBRID, MINIMIZED AVERAGE STRUCTURE
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