3zuu

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[[Image:3zuu.png|left|200px]]
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==THE STRUCTURE OF OST1 (D160A, S175D) KINASE IN COMPLEX WITH GOLD==
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<StructureSection load='3zuu' size='340' side='right' caption='[[3zuu]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zuu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZUU FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zut|3zut]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zuu RCSB], [http://www.ebi.ac.uk/pdbsum/3zuu PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SnRK [SNF1 (sucrose non-fermenting-1)-related protein kinase] 2.6 [open stomata 1 (OST1)] is well characterized at molecular and physiological levels to control stomata closure in response to water-deficit stress. OST1 is a member of a family of 10 protein kinases from Arabidopsis thaliana (SnRK2) that integrates abscisic acid (ABA)-dependent and ABA-independent signals to coordinate the cell response to osmotic stress. A subgroup of protein phosphatases type 2C binds OST1 and keeps the kinase dephosphorylated and inactive. Activation of OST1 relies on the ABA-dependent inhibition of the protein phosphatases type 2C and the subsequent self-phosphorylation of the kinase. The OST1 ABA-independent activation depends on a short sequence motif that is conserved among all the members of the SnRK2 family. However, little is known about the molecular mechanism underlying this regulation. The crystallographic structure of OST1 shows that ABA-independent regulation motif stabilizes the conformation of the kinase catalytically essential alpha C helix, and it provides the basis of the ABA-independent regulation mechanism for the SnRK2 family of protein kinases.
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The Structure of Arabidopsis thaliana OST1 Provides Insights into the Kinase Regulation Mechanism in Response to Osmotic Stress.,Yunta C, Martinez-Ripoll M, Zhu JK, Albert A J Mol Biol. 2011 Nov 18;414(1):135-44. Epub 2011 Oct 1. PMID:21983340<ref>PMID:21983340</ref>
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The line below this paragraph, containing "STRUCTURE_3zuu", creates the "Structure Box" on the page.
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{{STRUCTURE_3zuu| PDB=3zuu | SCENE= }}
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===THE STRUCTURE OF OST1 (D160A, S175D) KINASE IN COMPLEX WITH GOLD===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[ABA-regulated SNRK2 Protein Kinase|ABA-regulated SNRK2 Protein Kinase]]
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The line below this paragraph, {{ABSTRACT_PUBMED_21983340}}, adds the Publication Abstract to the page
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*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21983340 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21983340}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3zuu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUU OCA].
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==Reference==
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<ref group="xtra">PMID:021983340</ref><references group="xtra"/>
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[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]

Revision as of 07:53, 5 June 2014

THE STRUCTURE OF OST1 (D160A, S175D) KINASE IN COMPLEX WITH GOLD

3zuu, resolution 2.70Å

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