3zxu

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[[Image:3zxu.jpg|left|200px]]
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==Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast==
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<StructureSection load='3zxu' size='340' side='right' caption='[[3zxu]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLLA0B10142G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 Kluyveromyces lactis]), KLLA0D07612G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 Kluyveromyces lactis])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxu RCSB], [http://www.ebi.ac.uk/pdbsum/3zxu PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The proteins Ctf19, Okp1, Mcm21 and Ame1 are the components of COMA, a subassembly of budding-yeast kinetochores. We have determined the crystal structure of a conserved COMA subcomplex-the Ctf19-Mcm21 heterodimer-from Kluyveromyces lactis. Both proteins contain 'double-RWD' domains, which together form a Y-shaped framework with flexible N-terminal extensions. The kinetochore proteins Csm1, Spc24 and Spc25 have related single RWD domains, and Ctf19 and Mcm21 associate with pseudo-twofold symmetry analogous to that in the Csm1 homodimer and the Spc24-Spc25 heterodimer. The double-RWD domain core of the Ctf19-Mcm21 heterodimer is sufficient for association with Okp1-Ame1; the less conserved N-terminal regions may interact with components of a more extensive 'CTF19 complex'. Our structure shows the RWD domain to be a recurring module of kinetochore architecture that may be present in other kinetochore substructures. Like many eukaryotic molecular machines, kinetochores may have evolved from simpler assemblies by multiplication of a few ancestral modules.
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RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure.,Schmitzberger F, Harrison SC EMBO Rep. 2012 Mar 1;13(3):216-22. doi: 10.1038/embor.2012.1. PMID:22322944<ref>PMID:22322944</ref>
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The line below this paragraph, containing "STRUCTURE_3zxu", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3zxu| PDB=3zxu | SCENE= }}
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===Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22322944}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22322944 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22322944}}
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==About this Structure==
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[[3zxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA].
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==Reference==
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<ref group="xtra">PMID:022322944</ref><references group="xtra"/>
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[[Category: Kluyveromyces lactis]]
[[Category: Kluyveromyces lactis]]
[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]

Revision as of 07:57, 5 June 2014

Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast

3zxu, resolution 3.70Å

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