4afj

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[[Image:4afj.png|left|200px]]
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==5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors==
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<StructureSection load='4afj' size='340' side='right' caption='[[4afj]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4afj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AFJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AFJ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SJJ:5-(4-METHOXYPHENYL)-N-(PYRIDIN-4-YLMETHYL)-1,3-OXAZOLE-4-CARBOXAMIDE'>SJJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uw9|2uw9]], [[1o6k|1o6k]], [[1gng|1gng]], [[1h8f|1h8f]], [[1q3w|1q3w]], [[3zrk|3zrk]], [[1i09|1i09]], [[1o9u|1o9u]], [[2x37|2x37]], [[3zrm|3zrm]], [[4acg|4acg]], [[2jdr|2jdr]], [[1o6l|1o6l]], [[1j1b|1j1b]], [[1r0e|1r0e]], [[1q41|1q41]], [[2x39|2x39]], [[4ach|4ach]], [[3zrl|3zrl]], [[2jld|2jld]], [[1q3d|1q3d]], [[4acc|4acc]], [[1q5k|1q5k]], [[2jdo|2jdo]], [[4acd|4acd]], [[1pyx|1pyx]], [[1q4l|1q4l]], [[1j1c|1j1c]], [[1uv5|1uv5]], [[2xh5|2xh5]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4afj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4afj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4afj RCSB], [http://www.ebi.ac.uk/pdbsum/4afj PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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5-Aryl-4-carboxamide-1,3-oxazoles are a novel, potent and selective series of GSK-3 inhibitors. The optimization of the series to yield compounds with cell activity and brain permeability is described.
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5-Aryl-4-carboxamide-1,3-oxazoles: Potent and selective GSK-3 inhibitors.,Gentile G, Merlo G, Pozzan A, Bernasconi G, Bax B, Bamborough P, Bridges A, Carter P, Neu M, Yao G, Brough C, Cutler G, Coffin A, Belyanskaya S Bioorg Med Chem Lett. 2012 Mar 1;22(5):1989-94. Epub 2012 Jan 21. PMID:22310227<ref>PMID:22310227</ref>
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The line below this paragraph, containing "STRUCTURE_4afj", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_4afj| PDB=4afj | SCENE= }}
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===5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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<!--
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*[[Glycogen synthase kinase 3|Glycogen synthase kinase 3]]
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The line below this paragraph, {{ABSTRACT_PUBMED_22310227}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22310227 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22310227}}
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</StructureSection>
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==About this Structure==
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[[4afj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AFJ OCA].
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==Reference==
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<ref group="xtra">PMID:022310227</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bamborough, P.]]
[[Category: Bamborough, P.]]

Revision as of 08:12, 5 June 2014

5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors

4afj, resolution 1.98Å

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