3zya

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[[Image:3zya.png|left|200px]]
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==Human p38 MAP Kinase in Complex with 2-amino-phenylamino- dibenzosuberone==
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<StructureSection load='3zya' size='340' side='right' caption='[[3zya]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zya]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZYA FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2A8:2-AMINO-PHENYLAMINO-DIBENZOSUBERONE'>2A8</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2baj|2baj]], [[1wfc|1wfc]], [[3zsi|3zsi]], [[1w7h|1w7h]], [[1wbo|1wbo]], [[1kv2|1kv2]], [[1yqj|1yqj]], [[1bmk|1bmk]], [[1bl7|1bl7]], [[1zyj|1zyj]], [[1a9u|1a9u]], [[1wbt|1wbt]], [[2i0h|2i0h]], [[3zs5|3zs5]], [[2yiw|2yiw]], [[2baq|2baq]], [[1wbv|1wbv]], [[1zz2|1zz2]], [[1di9|1di9]], [[1w83|1w83]], [[1bl6|1bl6]], [[1m7q|1m7q]], [[3zsh|3zsh]], [[1ian|1ian]], [[1oz1|1oz1]], [[1wbn|1wbn]], [[2bak|2bak]], [[3zsg|3zsg]], [[2bal|2bal]], [[1wbs|1wbs]], [[1ouy|1ouy]], [[1ouk|1ouk]], [[2y8o|2y8o]], [[1r39|1r39]], [[2yis|2yis]], [[1kv1|1kv1]], [[1wbw|1wbw]], [[1w82|1w82]], [[2yix|2yix]], [[1r3c|1r3c]], [[1ove|1ove]], [[1w84|1w84]], [[1zzl|1zzl]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zya OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zya RCSB], [http://www.ebi.ac.uk/pdbsum/3zya PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Until now, a lack of inhibitors with high potency and selectivity in vivo has hampered investigation of the p38 mitogen-activated protein kinase (MAPK) signaling pathway. We describe the design of skepinone-L, which is, to our knowledge, the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, skepinone-L is a valuable probe for chemical biology research, and it may foster the development of a unique class of kinase inhibitors.
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Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.,Koeberle SC, Romir J, Fischer S, Koeberle A, Schattel V, Albrecht W, Grutter C, Werz O, Rauh D, Stehle T, Laufer SA Nat Chem Biol. 2011 Dec 25. doi: 10.1038/nchembio.761. PMID:22198732<ref>PMID:22198732</ref>
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The line below this paragraph, containing "STRUCTURE_3zya", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_3zya| PDB=3zya | SCENE= }}
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===Human p38 MAP Kinase in Complex with 2-amino-phenylamino- dibenzosuberone===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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<!--
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*[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]]
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The line below this paragraph, {{ABSTRACT_PUBMED_22198732}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22198732 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22198732}}
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</StructureSection>
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==About this Structure==
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[[3zya]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYA OCA].
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==Reference==
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<ref group="xtra">PMID:022198732</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mitogen-activated protein kinase]]
[[Category: Mitogen-activated protein kinase]]

Revision as of 08:26, 5 June 2014

Human p38 MAP Kinase in Complex with 2-amino-phenylamino- dibenzosuberone

3zya, resolution 1.90Å

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