4dvi

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[[Image:4dvi.jpg|left|200px]]
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==Crystal structure of Tankyrase 1 with IWR2==
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<StructureSection load='4dvi' size='340' side='right' caption='[[4dvi]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4dvi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DVI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2IW:4-[(3AR,4S,7R,7AS)-1,3-DIOXO-1,3,3A,4,7,7A-HEXAHYDRO-2H-4,7-METHANOISOINDOL-2-YL]-N-(4-METHYLQUINOLIN-8-YL)BENZAMIDE'>2IW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rf5|2rf5]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dvi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dvi RCSB], [http://www.ebi.ac.uk/pdbsum/4dvi PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tankyrases (TNKS1 and TNKS2) are key regulators of cellular processes such as telomere pathway and Wnt signaling. IWRs (inhibitors of Wnt response) have recently been identified as potent and selective inhibitors of tankyrases. However, it is not clear how these IWRs interact with tankyrases. Here we report the crystal structure of the catalytic domain of human TNKS1 in complex with IWR2, which reveals a novel binding site for tankyrase inhibitors. The TNKS1/IWR2 complex provides a molecular basis for their strong and specific interactions and suggests clues for further development of tankyrase inhibitors.
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Novel binding mode of a potent and selective tankyrase inhibitor.,Gunaydin H, Gu Y, Huang X PLoS One. 2012;7(3):e33740. Epub 2012 Mar 16. PMID:22438990<ref>PMID:22438990</ref>
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The line below this paragraph, containing "STRUCTURE_4dvi", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_4dvi| PDB=4dvi | SCENE= }}
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===Crystal structure of Tankyrase 1 with IWR2===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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<!--
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*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
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The line below this paragraph, {{ABSTRACT_PUBMED_22438990}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22438990 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22438990}}
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</StructureSection>
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==About this Structure==
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[[4dvi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVI OCA].
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==Reference==
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<ref group="xtra">PMID:022438990</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Huang, X.]]
[[Category: Huang, X.]]

Revision as of 08:27, 5 June 2014

Crystal structure of Tankyrase 1 with IWR2

4dvi, resolution 1.90Å

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