1bf5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1bf5.gif|left|200px]]<br /><applet load="1bf5" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1bf5.gif|left|200px]]
-
caption="1bf5, resolution 2.900&Aring;" />
+
 
-
'''TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX'''<br />
+
{{Structure
 +
|PDB= 1bf5 |SIZE=350|CAPTION= <scene name='initialview01'>1bf5</scene>, resolution 2.900&Aring;
 +
|SITE=
 +
|LIGAND=
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX'''
 +
 
==Overview==
==Overview==
Line 10: Line 19:
==About this Structure==
==About this Structure==
-
1BF5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BF5 OCA].
+
1BF5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BF5 OCA].
==Reference==
==Reference==
-
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA., Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell JE Jr, Kuriyan J, Cell. 1998 May 29;93(5):827-39. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9630226 9630226]
+
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA., Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell JE Jr, Kuriyan J, Cell. 1998 May 29;93(5):827-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9630226 9630226]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 26: Line 35:
[[Category: transcription factor]]
[[Category: transcription factor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:54:36 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:10:12 2008''

Revision as of 08:10, 20 March 2008

Image:1bf5.gif


PDB ID 1bf5

Drag the structure with the mouse to rotate
, resolution 2.900Å
Coordinates: save as pdb, mmCIF, xml



TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX


Contents

Overview

The crystal structure of the DNA complex of a STAT-1 homodimer has been determined at 2.9 A resolution. STAT-1 utilizes a DNA-binding domain with an immunoglobulin fold, similar to that of NFkappaB and the p53 tumor suppressor protein. The STAT-1 dimer forms a contiguous C-shaped clamp around DNA that is stabilized by reciprocal and highly specific interactions between the SH2 domain of one monomer and the C-terminal segment, phosphorylated on tyrosine, of the other. The phosphotyrosine-binding site of the SH2 domain in each monomer is coupled structurally to the DNA-binding domain, suggesting a potential role for the SH2-phosphotyrosine interaction in the stabilization of DNA interacting elements.

Disease

Known diseases associated with this structure: Mycobacterial infection, atypical, familial disseminated OMIM:[600555], STAT1 deficiency, complete OMIM:[600555]

About this Structure

1BF5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA., Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell JE Jr, Kuriyan J, Cell. 1998 May 29;93(5):827-39. PMID:9630226

Page seeded by OCA on Thu Mar 20 10:10:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bf5"
Personal tools