4dkz

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[[Image:4dkz.png|left|200px]]
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==Hairpin structure of a DNA dodecamer containing North-methanocarba-2'-deoxythymidine==
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<StructureSection load='4dkz' size='340' side='right' caption='[[4dkz]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4dkz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DKZ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0KZ:[(1R,2S,4S,5S)-2-HYDROXY-4-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)BICYCLO[3.1.0]HEX-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>0KZ</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dkz RCSB], [http://www.ebi.ac.uk/pdbsum/4dkz PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Incorporation of a bicyclo[3.1.0]hexane scaffold into the nucleoside sugar was devised to lock the embedded cyclopentane ring in conformations that mimic the furanose North and South sugar puckers. To analyze the effects of North-methanocarba-2'-deoxythymidine (N-MCdT) on the B-form DNA, we crystallized d(CGCGAA[mcTmcT]CGCG) with two N-MCdTs. Instead of a duplex, the 12mer forms a tetraloop hairpin, whereby loop N-MCdTs adopt the C4'-exo pucker (NE; P = 50 degrees ). Thus, the bicyclic framework does not limit the pucker to the anticipated C2'-exo range (NNW; P = -18 degrees ).
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The Conformationally Constrained N-Methanocarba-dT Analogue Adopts an Unexpected C4'-exo Sugar Pucker in the Structure of a DNA Hairpin.,Pallan PS, Marquez VE, Egli M Biochemistry. 2012 Mar 20. PMID:22409313<ref>PMID:22409313</ref>
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The line below this paragraph, containing "STRUCTURE_4dkz", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_4dkz| PDB=4dkz | SCENE= }}
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===Hairpin structure of a DNA dodecamer containing North-methanocarba-2'-deoxythymidine===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22409313}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22409313 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22409313}}
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==About this Structure==
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[[4dkz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKZ OCA].
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==Reference==
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<ref group="xtra">PMID:022409313</ref><references group="xtra"/>
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[[Category: Egli, M.]]
[[Category: Egli, M.]]
[[Category: Pallan, P S.]]
[[Category: Pallan, P S.]]

Revision as of 08:29, 5 June 2014

Hairpin structure of a DNA dodecamer containing North-methanocarba-2'-deoxythymidine

4dkz, resolution 1.80Å

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