1bg7

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[[Image:1bg7.gif|left|200px]]<br /><applet load="1bg7" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1bg7.gif|left|200px]]
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caption="1bg7, resolution 1.85&Aring;" />
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'''LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?'''<br />
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{{Structure
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|PDB= 1bg7 |SIZE=350|CAPTION= <scene name='initialview01'>1bg7</scene>, resolution 1.85&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1BG7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BG7 OCA].
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1BG7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BG7 OCA].
==Reference==
==Reference==
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Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?, Takagi H, Shi D, Ha Y, Allewell NM, Theil EC, J Biol Chem. 1998 Jul 24;273(30):18685-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9668036 9668036]
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Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?, Takagi H, Shi D, Ha Y, Allewell NM, Theil EC, J Biol Chem. 1998 Jul 24;273(30):18685-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9668036 9668036]
[[Category: Rana catesbeiana]]
[[Category: Rana catesbeiana]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: iron storage]]
[[Category: iron storage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:54:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:10:33 2008''

Revision as of 08:10, 20 March 2008

Image:1bg7.gif


PDB ID 1bg7

Drag the structure with the mouse to rotate
, resolution 1.85Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?


Overview

How and where iron exits from ferritin for cellular use is unknown. Twenty-four protein subunits create a cavity in ferritin where iron is concentrated >10(11)-fold as a mineral. Proline substitution for conserved leucine 134 (L134P) allowed normal assembly but increased iron exit rates. X-ray crystallography of H-L134P ferritin revealed localized unfolding at the 3-fold axis, also iron entry sites, consistent with shared use sites for iron exit and entry. The junction of three ferritin subunits appears to be a dynamic aperture with a "shutter" that cytoplasmic factors might open or close to regulate iron release in vivo.

About this Structure

1BG7 is a Single protein structure of sequence from Rana catesbeiana. Full crystallographic information is available from OCA.

Reference

Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?, Takagi H, Shi D, Ha Y, Allewell NM, Theil EC, J Biol Chem. 1998 Jul 24;273(30):18685-8. PMID:9668036

Page seeded by OCA on Thu Mar 20 10:10:33 2008

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