1jes

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[[Image:1jes.png|left|200px]]
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==Crystal Structure of a Copper-Mediated Base Pair in DNA==
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<StructureSection load='1jes' size='340' side='right' caption='[[1jes]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jes]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JES FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPY:2-DEOXYRIBOFURANOSYL-PYRIDINE-2,6-DICARBOXYLIC+ACID-5-MONOPHOSPHATE'>DPY</scene>, <scene name='pdbligand=DRP:2-DEOXYRIBOFURANOSYL-PYRIDINE-5-MONOPHOSPHATE'>DRP</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bna|1bna]], [[2zna|2zna]], [[3zna|3zna]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jes OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jes RCSB], [http://www.ebi.ac.uk/pdbsum/1jes PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.; Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am. Chem. Soc. 2000, 122, 10714-10715). To understand the structural consequences of introducing this novel base pair into DNA we have solved the crystal structure of a duplex containing the metallo-base pair. The structure shows that the bases pair as designed, but in a Z-DNA conformation. The structure also provides a structural explanation for the B- to Z-DNA transition in this duplex. Further solution studies demonstrate that the metallo-base pair is compatible with Z- or B-DNA conformations, depending on the duplex sequence.
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{{STRUCTURE_1jes| PDB=1jes | SCENE= }}
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Structure of a copper-mediated base pair in DNA.,Atwell S, Meggers E, Spraggon G, Schultz PG J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:11734038<ref>PMID:11734038</ref>
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===Crystal Structure of a Copper-Mediated Base Pair in DNA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_11734038}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1jes]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:011734038</ref><references group="xtra"/>
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[[Category: Atwell, S.]]
[[Category: Atwell, S.]]
[[Category: Meggers, E.]]
[[Category: Meggers, E.]]

Revision as of 05:31, 8 June 2014

Crystal Structure of a Copper-Mediated Base Pair in DNA

1jes, resolution 1.50Å

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