1f84
From Proteopedia
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| - | [[ | + | ==SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID== |
| + | <StructureSection load='1f84' size='340' side='right' caption='[[1f84]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1f84]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F84 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F84 FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f84 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1f84 RCSB], [http://www.ebi.ac.uk/pdbsum/1f84 PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Translation of the hepatitis C virus (HCV) polyprotein is initiated at an internal ribosome entry site (IRES) element in the 5' untranslated region of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG start codon as required for IRES-40S subunit complex formation. The data we present here show that two RNA stem loops, domains IIId and IIIe, are involved in IRES-40S subunit interaction. The structures of the two RNA domains were solved by NMR spectroscopy and reveal structural features that may explain their role in IRES function. | ||
| - | + | Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function.,Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:11101890<ref>PMID:11101890</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | == | + | |
| - | < | + | |
[[Category: Lancaster, A M.]] | [[Category: Lancaster, A M.]] | ||
[[Category: Lukavsky, P J.]] | [[Category: Lukavsky, P J.]] | ||
Revision as of 05:32, 8 June 2014
SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID
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