1fms

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{{Seed}}
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==Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)==
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[[Image:1fms.png|left|200px]]
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<StructureSection load='1fms' size='340' side='right' caption='[[1fms]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fms]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FMS FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D35:2,5-BIS{[4-(N-CYCLOHEXYLDIAMINOMETHYL)PHENYL]}FURAN'>D35</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fms OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fms RCSB], [http://www.ebi.ac.uk/pdbsum/1fms PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
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DNA minor groove interactions and the biological activity of 2,5-bis.,Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631<ref>PMID:11128631</ref>
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The line below this paragraph, containing "STRUCTURE_1fms", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_1fms| PDB=1fms | SCENE= }}
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===Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11128631}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11128631 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11128631}}
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==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMS OCA].
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==Reference==
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DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11128631 11128631]
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[[Category: Boykin, D W.]]
[[Category: Boykin, D W.]]
[[Category: Kumar, A.]]
[[Category: Kumar, A.]]
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[[Category: Neidle, S.]]
[[Category: Neidle, S.]]
[[Category: Simpson, I J.]]
[[Category: Simpson, I J.]]
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[[Category: Dna]]
[[Category: Dna-drug minor groove complex]]
[[Category: Dna-drug minor groove complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:31:24 2008''
 

Revision as of 05:37, 8 June 2014

Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)

1fms, resolution 1.90Å

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