1lpw

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[[Image:1lpw.png|left|200px]]
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==Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine==
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<StructureSection load='1lpw' size='340' side='right' caption='[[1lpw]], [[NMR_Ensembles_of_Models | 9 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lpw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LPW FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lmv|1lmv]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lpw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lpw RCSB], [http://www.ebi.ac.uk/pdbsum/1lpw PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pairing of a consensus sequence of the precursor (pre)-mRNA intron with a short region of the U2 small nuclear (sn)RNA during assembly of the eukaryotic spliceosome results in formation of a complementary helix of seven base pairs with a single unpaired adenosine residue. The 2' OH of this adenosine, called the branch site, brings about nucleophilic attack at the pre-mRNA 5' splice site in the first step of splicing. Another feature of this pairing is the phylogenetic conservation of a pseudouridine (psi) residue in U2 snRNA nearly opposite the branch site. We show that the presence of this psi in the pre-mRNA branch-site helix of Saccharomyces cerevisiae induces a dramatically altered architectural landscape compared with that of its unmodified counterpart. The psi-induced structure places the nucleophile in an accessible position for the first step of splicing.
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{{STRUCTURE_1lpw| PDB=1lpw | SCENE= }}
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Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine.,Newby MI, Greenbaum NL Nat Struct Biol. 2002 Dec;9(12):958-65. PMID:12426583<ref>PMID:12426583</ref>
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===Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_12426583}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1lpw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPW OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012426583</ref><ref group="xtra">PMID:012242344</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Greenbaum, N L.]]
[[Category: Greenbaum, N L.]]

Revision as of 05:39, 8 June 2014

Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine

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