2jwq
From Proteopedia
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| - | [[ | + | ==G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study== |
| + | <StructureSection load='2jwq' size='340' side='right' caption='[[2jwq]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JWQ FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G-quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex-interactive compounds for use in anticancer approaches. | ||
| - | + | G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study.,Hounsou C, Guittat L, Monchaud D, Jourdan M, Saettel N, Mergny JL, Teulade-Fichou MP ChemMedChem. 2007 May;2(5):655-66. PMID:17385760<ref>PMID:17385760</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Guittat, L.]] | [[Category: Guittat, L.]] | ||
[[Category: Hounsou, C.]] | [[Category: Hounsou, C.]] | ||
Revision as of 06:47, 9 June 2014
G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study
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