1uon

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[[Image:1uon.png|left|200px]]
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==REOVIRUS POLYMERASE LAMBDA-3 LOCALIZED BY ELECTRON CRYOMICROSCOPY OF VIRIONS AT 7.6-A RESOLUTION==
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<StructureSection load='1uon' size='340' side='right' caption='[[1uon]], [[Resolution|resolution]] 7.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1uon]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UON FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CH1:3-DEOXY-CYTIDINE-5-TRIPHOSPHATE'>CH1</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1muk|1muk]], [[1mwh|1mwh]], [[1n1h|1n1h]], [[1n35|1n35]], [[1n38|1n38]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uon OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uon RCSB], [http://www.ebi.ac.uk/pdbsum/1uon PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Reovirus is an icosahedral, double-stranded (ds) RNA virus that uses viral polymerases packaged within the viral core to transcribe its ten distinct plus-strand RNAs. To localize these polymerases, the structure of the reovirion was refined to a resolution of 7.6 A by cryo-electron microscopy (cryo-EM) and three-dimensional (3D) image reconstruction. X-ray crystal models of reovirus proteins, including polymerase lambda 3, were then fitted into the density map. Each copy of lambda 3 was found anchored to the inner surface of the icosahedral core shell, making major contacts with three molecules of shell protein lambda 1 and overlapping, but not centering on, a five-fold axis. The overlap explains why only one copy of lambda 3 is bound per vertex. lambda 3 is furthermore oriented with its transcript exit channel facing a small channel through the lambda 1 shell, suggesting how the nascent RNA is passed into the large external cavity of the pentameric capping enzyme complex formed by protein lambda 2.
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{{STRUCTURE_1uon| PDB=1uon | SCENE= }}
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Reovirus polymerase lambda 3 localized by cryo-electron microscopy of virions at a resolution of 7.6 A.,Zhang X, Walker SB, Chipman PR, Nibert ML, Baker TS Nat Struct Biol. 2003 Dec;10(12):1011-8. Epub 2003 Nov 9. PMID:14608373<ref>PMID:14608373</ref>
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===REOVIRUS POLYMERASE LAMBDA-3 LOCALIZED BY ELECTRON CRYOMICROSCOPY OF VIRIONS AT 7.6-A RESOLUTION===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_14608373}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1uon]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UON OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:014608373</ref><references group="xtra"/>
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[[Category: Reovirus sp.]]
[[Category: Reovirus sp.]]
[[Category: Baker, T S.]]
[[Category: Baker, T S.]]

Revision as of 06:47, 9 June 2014

REOVIRUS POLYMERASE LAMBDA-3 LOCALIZED BY ELECTRON CRYOMICROSCOPY OF VIRIONS AT 7.6-A RESOLUTION

1uon, resolution 7.60Å

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