2akf
From Proteopedia
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| - | [[ | + | ==Crystal structure of the coiled-coil domain of coronin 1== |
| + | <StructureSection load='2akf' size='340' side='right' caption='[[2akf]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2akf]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AKF FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2akf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2akf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2akf RCSB], [http://www.ebi.ac.uk/pdbsum/2akf PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | In recent years, short coiled coils have been used for applications ranging from biomaterial to medical sciences. For many of these applications knowledge of the factors that control the topology of the engineered protein systems is essential. Here, we demonstrate that trimerization of short coiled coils is determined by a distinct structural motif that encompasses specific networks of surface salt bridges and optimal hydrophobic packing interactions. The motif is conserved among intracellular, extracellular, viral, and synthetic proteins and defines a universal molecular determinant for trimer formation of short coiled coils. In addition to being of particular interest for the biotechnological production of candidate therapeutic proteins, these findings may be of interest for viral drug development strategies. | ||
| - | + | A conserved trimerization motif controls the topology of short coiled coils.,Kammerer RA, Kostrewa D, Progias P, Honnappa S, Avila D, Lustig A, Winkler FK, Pieters J, Steinmetz MO Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13891-6. Epub 2005 Sep 19. PMID:16172398<ref>PMID:16172398</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Avila, D.]] | [[Category: Avila, D.]] | ||
[[Category: Honnappa, S.]] | [[Category: Honnappa, S.]] | ||
Revision as of 06:48, 9 June 2014
Crystal structure of the coiled-coil domain of coronin 1
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