2jsm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2jsm" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:2jsm.png|left|200px]]
+
==MONOMERIC HUMAN TELOMERE DNA TETRAPLEX WITH 3+1 STRAND FOLD TOPOLOGY, TWO EDGEWISE LOOPS AND DOUBLE-CHAIN REVERSAL LOOP, NMR, 10 STRUCTURES, Form 1 Natural==
 +
<StructureSection load='2jsm' size='340' side='right' caption='[[2jsm]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2jsm]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSM FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[143d|143d]], [[186d|186d]], [[1k8p|1k8p]], [[2aqy|2aqy]], [[2jsk|2jsk]], [[2jsl|2jsl]], [[2jsq|2jsq]]</td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsm RCSB], [http://www.ebi.ac.uk/pdbsum/2jsm PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K(+) solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one double-chain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds.
-
{{STRUCTURE_2jsm| PDB=2jsm | SCENE= }}
+
Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution.,Phan AT, Kuryavyi V, Luu KN, Patel DJ Nucleic Acids Res. 2007;35(19):6517-25. Epub 2007 Sep 25. PMID:17895279<ref>PMID:17895279</ref>
-
===MONOMERIC HUMAN TELOMERE DNA TETRAPLEX WITH 3+1 STRAND FOLD TOPOLOGY, TWO EDGEWISE LOOPS AND DOUBLE-CHAIN REVERSAL LOOP, NMR, 10 STRUCTURES, Form 1 Natural===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_17895279}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[2jsm]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSM OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:017895279</ref><references group="xtra"/>
+
[[Category: Kuryavyi, V V.]]
[[Category: Kuryavyi, V V.]]
[[Category: Luu, K N.]]
[[Category: Luu, K N.]]

Revision as of 06:52, 9 June 2014

MONOMERIC HUMAN TELOMERE DNA TETRAPLEX WITH 3+1 STRAND FOLD TOPOLOGY, TWO EDGEWISE LOOPS AND DOUBLE-CHAIN REVERSAL LOOP, NMR, 10 STRUCTURES, Form 1 Natural

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jsm"
Views
Personal tools
Navigation
Toolbox