28sp
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| - | [[ | + | ==NMR STRUCTURE OF THE MOST CONSERVED RNA MOTIF IN SRP RNA== |
| + | <StructureSection load='28sp' size='340' side='right' caption='[[28sp]], [[NMR_Ensembles_of_Models | 7 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[28sp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=28SP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=28SP FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=28sp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=28sp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=28sp RCSB], [http://www.ebi.ac.uk/pdbsum/28sp PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The signal recognition particle (SRP) directs translating ribosomes to the protein translocation apparatus of endoplasmic reticulum (ER) membrane or the bacterial plasma membrane. The SRP is universally conserved, and in prokaryotes consists of two essential subunits, SRP RNA and SRP54, the latter of which binds to signal sequences on the nascent protein chains. Here we describe the solution NMR structure of a 28-mer RNA composing the most conserved part of SRP RNA to which SRP54 binds. Central to this function is a six-nucleotide internal loop that assumes a novel Mg2+-dependent structure with unusual cross-strand interactions; besides a cross-strand A/A stack, two guanines form hydrogen bonds with opposite-strand phosphates. The structure completely explains the phylogenetic conservation of the loop bases, underlining its importance for SRP54 binding and SRP function. | ||
| - | + | Structure of the most conserved internal loop in SRP RNA.,Schmitz U, James TL, Lukavsky P, Walter P Nat Struct Biol. 1999 Jul;6(7):634-8. PMID:10404218<ref>PMID:10404218</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: James, T L.]] | [[Category: James, T L.]] | ||
Revision as of 06:52, 9 June 2014
NMR STRUCTURE OF THE MOST CONSERVED RNA MOTIF IN SRP RNA
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