1bjt
From Proteopedia
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| - | [[Image:1bjt.gif|left|200px]] | + | [[Image:1bjt.gif|left|200px]] |
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| - | '''TOPOISOMERASE II RESIDUES 409-1201''' | + | {{Structure |
| + | |PDB= 1bjt |SIZE=350|CAPTION= <scene name='initialview01'>1bjt</scene>, resolution 2.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''TOPOISOMERASE II RESIDUES 409-1201''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BJT is a [ | + | 1BJT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJT OCA]. |
==Reference== | ==Reference== | ||
| - | Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands., Fass D, Bogden CE, Berger JM, Nat Struct Biol. 1999 Apr;6(4):322-6. PMID:[http:// | + | Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands., Fass D, Bogden CE, Berger JM, Nat Struct Biol. 1999 Apr;6(4):322-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10201398 10201398] |
[[Category: DNA topoisomerase (ATP-hydrolyzing)]] | [[Category: DNA topoisomerase (ATP-hydrolyzing)]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
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[[Category: topoisomerase]] | [[Category: topoisomerase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:11:59 2008'' |
Revision as of 08:11, 20 March 2008
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| , resolution 2.5Å | |||||||
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| Activity: | DNA topoisomerase (ATP-hydrolyzing), with EC number 5.99.1.3 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
TOPOISOMERASE II RESIDUES 409-1201
Overview
Type II DNA topoisomerases mediate the passage of one DNA duplex through a transient break in another, an event essential for chromosome segregation and cell viability. The active sites of the type II topoisomerase dimer associate covalently with the DNA break-points and must separate by at least the width of the second DNA duplex to accommodate transport. A new structure of the Saccharomyces cerevisiae topoisomerase II DNA-binding and cleavage core suggests that in addition to conformational changes in the DNA-opening platform, a dramatic reorganization of accessory domains may occur during catalysis. These conformational differences have implications for both the DNA-breaking and duplex-transport events in the topo II reaction mechanism, suggest a mechanism by which two distinct drug-resistance loci interact, and illustrate the scope of structural changes in the cycling of molecular machines.
About this Structure
1BJT is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands., Fass D, Bogden CE, Berger JM, Nat Struct Biol. 1999 Apr;6(4):322-6. PMID:10201398
Page seeded by OCA on Thu Mar 20 10:11:59 2008
