2qs6

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[[Image:2qs6.png|left|200px]]
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==Structure of a Hoogsteen antiparallel duplex with extra-helical thymines==
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<StructureSection load='2qs6' size='340' side='right' caption='[[2qs6]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qs6]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QS6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QS6 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qs6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qs6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qs6 RCSB], [http://www.ebi.ac.uk/pdbsum/2qs6 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We present the crystal structure of the DNA duplex formed by d(ATATATCT). The crystals contain seven stacked antiparallel duplexes in the asymmetric unit with A.T Hoogsteen base pairs. The terminal CT sequences bend over so that the thymines enter the minor groove and form a hydrogen bond with thymine 2 of the complementary strand in the Hoogsteen duplex. Cytosines occupy extra-helical positions; they contribute to the crystal lattice through various kinds of interactions, including a unique CAA triplet. The presence of thymine in the minor groove apparently contributes to the stability of the DNA duplex in the Hoogsteen conformation. These observations open the way toward finding under what conditions the Hoogsteen duplex may be stabilized in vivo. The present crystal structure also confirms the tendency of A.T-rich oligonucleotides to crystallize as long helical stacks of duplexes.
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{{STRUCTURE_2qs6| PDB=2qs6 | SCENE= }}
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Stabilization by extra-helical thymines of a DNA duplex with Hoogsteen base pairs.,Pous J, Urpi L, Subirana JA, Gouyette C, Navaza J, Campos JL J Am Chem Soc. 2008 May 28;130(21):6755-60. Epub 2008 May 1. PMID:18447354<ref>PMID:18447354</ref>
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===Structure of a Hoogsteen antiparallel duplex with extra-helical thymines===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18447354}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2qs6]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QS6 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018447354</ref><references group="xtra"/>
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[[Category: Campos, J L.]]
[[Category: Campos, J L.]]
[[Category: Gouyette, C.]]
[[Category: Gouyette, C.]]

Revision as of 06:59, 9 June 2014

Structure of a Hoogsteen antiparallel duplex with extra-helical thymines

2qs6, resolution 3.08Å

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