1bk6

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[[Image:1bk6.gif|left|200px]]<br /><applet load="1bk6" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1bk6.gif|left|200px]]
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caption="1bk6, resolution 2.8&Aring;" />
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'''KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS'''<br />
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{{Structure
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|PDB= 1bk6 |SIZE=350|CAPTION= <scene name='initialview01'>1bk6</scene>, resolution 2.8&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= SRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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}}
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'''KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1BK6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BK6 OCA].
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1BK6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BK6 OCA].
==Reference==
==Reference==
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Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha., Conti E, Uy M, Leighton L, Blobel G, Kuriyan J, Cell. 1998 Jul 24;94(2):193-204. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9695948 9695948]
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Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha., Conti E, Uy M, Leighton L, Blobel G, Kuriyan J, Cell. 1998 Jul 24;94(2):193-204. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9695948 9695948]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein transport]]
[[Category: protein transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:56:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:12:08 2008''

Revision as of 08:12, 20 March 2008

Image:1bk6.gif


PDB ID 1bk6

Drag the structure with the mouse to rotate
, resolution 2.8Å
Gene: SRP1 (Saccharomyces cerevisiae)
Coordinates: save as pdb, mmCIF, xml



KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS


Overview

Selective nuclear import is mediated by nuclear localization signals (NLSs) and cognate transport factors known as karyopherins or importins. Karyopherin alpha recognizes "classical" monopartite and bipartite NLSs. We report the crystal structure of a 50 kDa fragment of the 60 kDa yeast karyopherin alpha, in the absence and presence of a monopartite NLS peptide at 2.2 A and 2.8 A resolution, respectively. The structure shows a tandem array of ten armadillo repeats, organized in a right-handed superhelix of helices. Binding of the NLS peptide occurs at two sites within a helical surface groove that is lined by conserved residues. The structure reveals the determinants of NLS specificity and suggests a model for the recognition of bipartite NLSs.

About this Structure

1BK6 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha., Conti E, Uy M, Leighton L, Blobel G, Kuriyan J, Cell. 1998 Jul 24;94(2):193-204. PMID:9695948

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