1w7z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1w7z" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:1w7z.png|left|200px]]
+
==CRYSTAL STRUCTURE OF THE FREE (UNCOMPLEXED) ECBALLIUM ELATERIUM TRYPSIN INHIBITOR (EETI-II)==
 +
<StructureSection load='1w7z' size='340' side='right' caption='[[1w7z]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1w7z]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecballium_elaterium Ecballium elaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W7Z FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
 +
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h9h|1h9h]], [[1h9i|1h9i]], [[2c4b|2c4b]], [[2eti|2eti]], [[2let|2let]]</td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w7z RCSB], [http://www.ebi.ac.uk/pdbsum/1w7z PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The Ecballium elaterium trypsin inhibitor II (EETI-II) belongs to the family of squash inhibitors and is one of the strongest inhibitors known for trypsin. The eight independent molecules of EETI-II in the crystal structure reported here provide a good opportunity to test the hypothesis that this small cystine-knot protein (knottin) is sufficiently rigid to be used as a molecular scaffold for protein-engineering purposes. To extend this test, the structures of two complexes of EETI-II with trypsin have also been determined, one carrying a four-amino-acid mutation of EETI-II. The remarkable similarity of these structures confirms the rigidity of the molecular framework and hence its suitability as a molecular scaffold.
-
{{STRUCTURE_1w7z| PDB=1w7z | SCENE= }}
+
Structure of Ecballium elaterium trypsin inhibitor II (EETI-II): a rigid molecular scaffold.,Kratzner R, Debreczeni JE, Pape T, Schneider TR, Wentzel A, Kolmar H, Sheldrick GM, Uson I Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1255-62. Epub 2005, Aug 16. PMID:16131759<ref>PMID:16131759</ref>
-
===CRYSTAL STRUCTURE OF THE FREE (UNCOMPLEXED) ECBALLIUM ELATERIUM TRYPSIN INHIBITOR (EETI-II)===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_16131759}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[1w7z]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecballium_elaterium Ecballium elaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7Z OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:016131759</ref><references group="xtra"/>
+
[[Category: Ecballium elaterium]]
[[Category: Ecballium elaterium]]
[[Category: Debreczeni, J E.]]
[[Category: Debreczeni, J E.]]

Revision as of 06:59, 9 June 2014

CRYSTAL STRUCTURE OF THE FREE (UNCOMPLEXED) ECBALLIUM ELATERIUM TRYPSIN INHIBITOR (EETI-II)

1w7z, resolution 1.67Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1w7z"
Views
Personal tools
Navigation
Toolbox