1ysv

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[[Image:1ysv.png|left|200px]]
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==Solution structure of the central region of the human GluR-B R/G pre-mRNA==
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<StructureSection load='1ysv' size='340' side='right' caption='[[1ysv]], [[NMR_Ensembles_of_Models | 13 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ysv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YSV FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ysv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ysv RCSB], [http://www.ebi.ac.uk/pdbsum/1ysv PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.
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{{STRUCTURE_1ysv| PDB=1ysv | SCENE= }}
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A novel RNA pentaloop fold involved in targeting ADAR2.,Stefl R, Allain FH RNA. 2005 May;11(5):592-7. PMID:15840813<ref>PMID:15840813</ref>
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===Solution structure of the central region of the human GluR-B R/G pre-mRNA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15840813}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1ysv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015840813</ref><references group="xtra"/>
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[[Category: Allain, F H.]]
[[Category: Allain, F H.]]
[[Category: Stefl, R.]]
[[Category: Stefl, R.]]

Revision as of 07:05, 9 June 2014

Solution structure of the central region of the human GluR-B R/G pre-mRNA

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