1qtg

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[[Image:1qtg.png|left|200px]]
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==AVERAGED NMR MODEL OF SWITCH ARC, A DOUBLE MUTANT OF ARC REPRESSOR==
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<StructureSection load='1qtg' size='340' side='right' caption='[[1qtg]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qtg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QTG FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1arr|1arr]], [[1par|1par]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qtg RCSB], [http://www.ebi.ac.uk/pdbsum/1qtg PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A "switch" mutant of the Arc repressor homodimer was constructed by interchanging the sequence positions of a hydrophobic core residue, leucine 12, and an adjacent surface polar residue, asparagine 11, in each strand of an intersubunit beta sheet. The mutant protein adopts a fold in which each beta strand is replaced by a right-handed helix and side chains in this region undergo significant repacking. The observed structural changes allow the protein to maintain solvent exposure of polar side chains and optimal burial of hydrophobic side chains. These results suggest that new protein folds can evolve from existing folds without drastic or large-scale mutagenesis.
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{{STRUCTURE_1qtg| PDB=1qtg | SCENE= }}
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Evolution of a protein fold in vitro.,Cordes MH, Walsh NP, McKnight CJ, Sauer RT Science. 1999 Apr 9;284(5412):325-8. PMID:10195898<ref>PMID:10195898</ref>
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===AVERAGED NMR MODEL OF SWITCH ARC, A DOUBLE MUTANT OF ARC REPRESSOR===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_10195898}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1qtg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTG OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:010195898</ref><references group="xtra"/>
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[[Category: Enterobacteria phage p22]]
[[Category: Enterobacteria phage p22]]
[[Category: Cordes, M H.J.]]
[[Category: Cordes, M H.J.]]

Revision as of 07:10, 9 June 2014

AVERAGED NMR MODEL OF SWITCH ARC, A DOUBLE MUTANT OF ARC REPRESSOR

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