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4ovz
From Proteopedia
(Difference between revisions)
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<StructureSection load='4ovz' size='340' side='right' caption='[[4ovz]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4ovz' size='340' side='right' caption='[[4ovz]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ovz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVZ OCA]. <br> | + | <table><tr><td colspan='2'>[[4ovz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_urbani Sars coronavirus urbani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OVZ FirstGlance]. <br> |
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P85:N-[(4-FLUOROPHENYL)METHYL]-1-[(1R)-1-NAPHTHALEN-1-YLETHYL]PIPERIDINE-4-CARBOXAMIDE'>P85</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br> | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P85:N-[(4-FLUOROPHENYL)METHYL]-1-[(1R)-1-NAPHTHALEN-1-YLETHYL]PIPERIDINE-4-CARBOXAMIDE'>P85</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br> | ||
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr> | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr> | ||
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ovz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ovz RCSB], [http://www.ebi.ac.uk/pdbsum/4ovz PDBsum]</span></td></tr> | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ovz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ovz RCSB], [http://www.ebi.ac.uk/pdbsum/4ovz PDBsum]</span></td></tr> | ||
<table> | <table> | ||
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X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases.,Baez-Santos YM, Barraza SJ, Wilson MW, Agius MP, Mielech AM, Davis NM, Baker SC, Larsen SD, Mesecar AD J Med Chem. 2014 Mar 27;57(6):2393-412. doi: 10.1021/jm401712t. Epub 2014 Mar 14. PMID:24568342<ref>PMID:24568342</ref> | X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases.,Baez-Santos YM, Barraza SJ, Wilson MW, Agius MP, Mielech AM, Davis NM, Baker SC, Larsen SD, Mesecar AD J Med Chem. 2014 Mar 27;57(6):2393-412. doi: 10.1021/jm401712t. Epub 2014 Mar 14. PMID:24568342<ref>PMID:24568342</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
| Line 20: | Line 19: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Sars coronavirus urbani]] | ||
[[Category: Baez-Santos, Y M.]] | [[Category: Baez-Santos, Y M.]] | ||
[[Category: Mesecar, A.]] | [[Category: Mesecar, A.]] | ||
Revision as of 06:20, 11 June 2014
X-Ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases
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Categories: Sars coronavirus urbani | Baez-Santos, Y M. | Mesecar, A. | Complex | Coronavirus | Cov | Deubiquitinating enzyme | Dub | Hcov | Human coronavirus | Hydrolase-hydrolase inhibitor complex | Mer | Middle east respiratory syndrome | Plpro | Protease inhibitor | Sar | Severe acute respiratory syndrome
