4cqw
From Proteopedia
(Difference between revisions)
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cqw RCSB], [http://www.ebi.ac.uk/pdbsum/4cqw PDBsum]</span></td></tr> | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cqw RCSB], [http://www.ebi.ac.uk/pdbsum/4cqw PDBsum]</span></td></tr> | ||
<table> | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mutant H5N1 influenza viruses have been isolated from humans that have increased human receptor avidity. We have compared the receptor binding properties of these mutants with those of wild-type viruses, and determined the structures of their haemagglutinins in complex with receptor analogues. Mutants from Vietnam bind tighter to human receptor by acquiring basic residues near the receptor binding site. They bind more weakly to avian receptor because they lack specific interactions between Asn-186 and Gln-226. In contrast, a double mutant, Delta133/Ile155Thr, isolated in Egypt has greater avidity for human receptor while retaining wild-type avidity for avian receptor. Despite these increases in human receptor binding, none of the mutants prefers human receptor, unlike aerosol transmissible H5N1 viruses. Nevertheless, mutants with high avidity for both human and avian receptors may be intermediates in the evolution of H5N1 viruses that could infect both humans and poultry. | ||
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| + | Enhanced human receptor binding by H5 haemagglutinins.,Xiong X, Xiao H, Martin SR, Coombs PJ, Liu J, Collins PJ, Vachieri SG, Walker PA, Lin YP, McCauley JW, Gamblin SJ, Skehel JJ Virology. 2014 May;456-457:179-87. doi: 10.1016/j.virol.2014.03.008. Epub 2014, Apr 12. PMID:24889237<ref>PMID:24889237</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:33, 11 June 2014
H5 (tyTy) Del133/Ile155Thr Mutant Haemagglutinin in Complex with Avian Receptor Analogue 3'SLN
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Categories: Collins, P J. | Coombs, P J. | Gamblin, S J. | Lin, Y P. | Liu, J. | Martin, S R. | McCauley, J W. | Skehel, J J. | Vachieri, S G. | Walker, P A. | Xiao, H. | Xiong, X. | 3'sln | 3sln | 6'sln | 6sln | Avian flu | Glycoprotein | Haemagglutinin | Lsta | Sialic acid | Sialyllactosamine | Viral protein | Virus receptor
