1bqo

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[[Image:1bqo.gif|left|200px]]<br /><applet load="1bqo" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1bqo.gif|left|200px]]
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caption="1bqo, resolution 2.3&Aring;" />
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'''DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS'''<br />
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{{Structure
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|PDB= 1bqo |SIZE=350|CAPTION= <scene name='initialview01'>1bqo</scene>, resolution 2.3&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=N25:1,3-BIS-(4-METHOXY-BENZENESULFONYL)-5,5-DIMETHYL-HEXAHYDRO-PYRIMIDINE-2-CARBOXYLIC ACID HYDROXYAMIDE'>N25</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17]
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|GENE=
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}}
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'''DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS'''
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==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1BQO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=N25:'>N25</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQO OCA].
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1BQO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQO OCA].
==Reference==
==Reference==
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Discovery of potent, achiral matrix metalloproteinase inhibitors., Pikul S, McDow Dunham KL, Almstead NG, De B, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Rydel T, Dunaway CM, Gu F, Mieling GE, J Med Chem. 1998 Sep 10;41(19):3568-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9733482 9733482]
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Discovery of potent, achiral matrix metalloproteinase inhibitors., Pikul S, McDow Dunham KL, Almstead NG, De B, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Rydel T, Dunaway CM, Gu F, Mieling GE, J Med Chem. 1998 Sep 10;41(19):3568-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9733482 9733482]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: structure-based drug design]]
[[Category: structure-based drug design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:58:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:14:30 2008''

Revision as of 08:14, 20 March 2008

Image:1bqo.gif


PDB ID 1bqo

Drag the structure with the mouse to rotate
, resolution 2.3Å
Ligands: , and
Activity: Stromelysin 1, with EC number 3.4.24.17
Coordinates: save as pdb, mmCIF, xml



DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS


Disease

Known diseases associated with this structure: Coronary heart disease, susceptibility to OMIM:[185250]

About this Structure

1BQO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of potent, achiral matrix metalloproteinase inhibitors., Pikul S, McDow Dunham KL, Almstead NG, De B, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Rydel T, Dunaway CM, Gu F, Mieling GE, J Med Chem. 1998 Sep 10;41(19):3568-71. PMID:9733482

Page seeded by OCA on Thu Mar 20 10:14:30 2008

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OCA

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