3ukc
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==(S)-cEt-BNA decamer structure== |
| + | <StructureSection load='3ukc' size='340' side='right' caption='[[3ukc]], [[Resolution|resolution]] 1.54Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ukc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UKC FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=1TL:1-{2,5-ANHYDRO-6-DEOXY-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-MANNOFURANOSYL}PYRIMIDINE-2,4(1H,3H)-DIONE'>1TL</scene></td></tr> | ||
| + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ukb|3ukb]], [[3uke|3uke]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ukc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ukc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ukc RCSB], [http://www.ebi.ac.uk/pdbsum/3ukc PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2',4'-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal structures of DNAs with cMOE or cEt BNA residues reveal their conformational preferences. Comparisons with MOE and LNA structures allow insights into their favourable properties for AON applications. | ||
| - | + | Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.,Pallan PS, Allerson CR, Berdeja A, Seth PP, Swayze EE, Prakash TP, Egli M Chem Commun (Camb). 2012 May 22. PMID:22614180<ref>PMID:22614180</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Egli, M.]] | [[Category: Egli, M.]] | ||
[[Category: Pallan, P S.]] | [[Category: Pallan, P S.]] | ||
Revision as of 09:07, 11 June 2014
(S)-cEt-BNA decamer structure
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