1bsx
From Proteopedia
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| - | [[Image:1bsx.gif|left|200px]] | + | [[Image:1bsx.gif|left|200px]] |
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| - | '''STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS''' | + | {{Structure |
| + | |PDB= 1bsx |SIZE=350|CAPTION= <scene name='initialview01'>1bsx</scene>, resolution 3.7Å | ||
| + | |SITE= <scene name='pdbsite=A:Nr-Box+Binding+Site'>A</scene> and <scene name='pdbsite=B:Nr-Box+Binding+Site'>B</scene> | ||
| + | |LIGAND= <scene name='pdbligand=T3:3,5,3'TRIIODOTHYRONINE'>T3</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BSX is a [ | + | 1BSX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BSX OCA]. |
==Reference== | ==Reference== | ||
| - | Structure and specificity of nuclear receptor-coactivator interactions., Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR, Genes Dev. 1998 Nov 1;12(21):3343-56. PMID:[http:// | + | Structure and specificity of nuclear receptor-coactivator interactions., Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR, Genes Dev. 1998 Nov 1;12(21):3343-56. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9808622 9808622] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Yamamoto, K R.]] | [[Category: Yamamoto, K R.]] | ||
[[Category: T3]] | [[Category: T3]] | ||
| - | [[Category: | + | [[Category: coactivator]] |
[[Category: grip1]] | [[Category: grip1]] | ||
| - | [[Category: nuclear | + | [[Category: nuclear receptor]] |
[[Category: specificity interaction site]] | [[Category: specificity interaction site]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:15:23 2008'' |
Revision as of 08:15, 20 March 2008
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| , resolution 3.7Å | |||||||
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| Sites: | and | ||||||
| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS
Contents |
Overview
Combinatorial regulation of transcription implies flexible yet precise assembly of multiprotein regulatory complexes in response to signals. Biochemical and crystallographic analyses revealed that hormone binding leads to the formation of a hydrophobic groove within the ligand binding domain (LBD) of the thyroid hormone receptor that interacts with an LxxLL motif-containing alpha-helix from GRIP1, a coactivator. Residues immediately adjacent to the motif modulate the affinity of the interaction; the motif and the adjacent sequences are employed to different extents in binding to different receptors. Such interactions of amphipathic alpha-helices with hydrophobic grooves define protein interfaces in other regulatory complexes as well. We suggest that these common structural elements impart flexibility to combinatorial regulation, whereas side chains at the interface impart specificity.
Disease
Known diseases associated with this structure: Thyroid hormone resistance OMIM:[190160], Thyroid hormone resistance, autosomal recessive OMIM:[190160]
About this Structure
1BSX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure and specificity of nuclear receptor-coactivator interactions., Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR, Genes Dev. 1998 Nov 1;12(21):3343-56. PMID:9808622
Page seeded by OCA on Thu Mar 20 10:15:23 2008
