4ei6

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[[Image:4ei6.png|left|200px]]
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==Structure of XV19 Valpha1-Vbeta16 Type-II Natural Killer T cell receptor==
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<StructureSection load='4ei6' size='340' side='right' caption='[[4ei6]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ei6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EI6 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ei5|4ei5]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ei6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ei6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ei6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ei6 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Natural killer T cells (NKT cells) are divided into type I and type II subsets on the basis of differences in their T cell antigen receptor (TCR) repertoire and CD1d-antigen specificity. Although the mode by which type I NKT cell TCRs recognize CD1d-antigen has been established, how type II NKT cell TCRs engage CD1d-antigen is unknown. Here we provide a basis for how a type II NKT cell TCR, XV19, recognized CD1d-sulfatide. The XV19 TCR bound orthogonally above the A' pocket of CD1d, in contrast to the parallel docking of type I NKT cell TCRs over the F' pocket of CD1d. At the XV19 TCR-CD1d-sulfatide interface, the TCRalpha and TCRbeta chains sat centrally on CD1d, where the malleable CDR3 loops dominated interactions with CD1d-sulfatide. Accordingly, we highlight the diverse mechanisms by which NKT cell TCRs can bind CD1d and account for the distinct antigen specificity of type II NKT cells.
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{{STRUCTURE_4ei6| PDB=4ei6 | SCENE= }}
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Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor.,Patel O, Pellicci DG, Gras S, Sandoval-Romero ML, Uldrich AP, Mallevaey T, Clarke AJ, Le Nours J, Theodossis A, Cardell SL, Gapin L, Godfrey DI, Rossjohn J Nat Immunol. 2012 Jul 22. doi: 10.1038/ni.2372. PMID:22820603<ref>PMID:22820603</ref>
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===Structure of XV19 Valpha1-Vbeta16 Type-II Natural Killer T cell receptor===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22820603}}
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==See Also==
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*[[T-cell receptor|T-cell receptor]]
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==About this Structure==
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== References ==
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[[4ei6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus,_homo_sapiens Mus musculus, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EI6 OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:022820603</ref><references group="xtra"/>
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus, homo sapiens]]
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[[Category: Patel, O.]]
[[Category: Patel, O.]]
[[Category: Rossjohn, J.]]
[[Category: Rossjohn, J.]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Natural killer t cell receptor]]
[[Category: Natural killer t cell receptor]]

Revision as of 09:10, 11 June 2014

Structure of XV19 Valpha1-Vbeta16 Type-II Natural Killer T cell receptor

4ei6, resolution 1.60Å

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