1buo
From Proteopedia
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| - | [[Image:1buo.gif|left|200px]] | + | [[Image:1buo.gif|left|200px]] |
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| - | '''BTB DOMAIN FROM PLZF''' | + | {{Structure |
| + | |PDB= 1buo |SIZE=350|CAPTION= <scene name='initialview01'>1buo</scene>, resolution 1.9Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''BTB DOMAIN FROM PLZF''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BUO is a [ | + | 1BUO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUO OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the BTB domain from PLZF., Ahmad KF, Engel CK, Prive GG, Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12123-8. PMID:[http:// | + | Crystal structure of the BTB domain from PLZF., Ahmad KF, Engel CK, Prive GG, Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12123-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9770450 9770450] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: zinc-finger protein]] | [[Category: zinc-finger protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:16:00 2008'' |
Revision as of 08:16, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
BTB DOMAIN FROM PLZF
Contents |
Overview
The BTB domain (also known as the POZ domain) is an evolutionarily conserved protein-protein interaction motif found at the N terminus of 5-10% of C2H2-type zinc-finger transcription factors, as well as in some actin-associated proteins bearing the kelch motif. Many BTB proteins are transcriptional regulators that mediate gene expression through the control of chromatin conformation. In the human promyelocytic leukemia zinc finger (PLZF) protein, the BTB domain has transcriptional repression activity, directs the protein to a nuclear punctate pattern, and interacts with components of the histone deacetylase complex. The association of the PLZF BTB domain with the histone deacetylase complex provides a mechanism of linking the transcription factor with enzymatic activities that regulate chromatin conformation. The crystal structure of the BTB domain of PLZF was determined at 1.9 A resolution and reveals a tightly intertwined dimer with an extensive hydrophobic interface. Approximately one-quarter of the monomer surface area is involved in the dimer intermolecular contact. These features are typical of obligate homodimers, and we expect the full-length PLZF protein to exist as a branched transcription factor with two C-terminal DNA-binding regions. A surface-exposed groove lined with conserved amino acids is formed at the dimer interface, suggestive of a peptide-binding site. This groove may represent the site of interaction of the PLZF BTB domain with nuclear corepressors or other nuclear proteins.
Disease
Known diseases associated with this structure: Leukemia, acute promyelocytic, PL2F/RARA type OMIM:[176797]
About this Structure
1BUO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the BTB domain from PLZF., Ahmad KF, Engel CK, Prive GG, Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12123-8. PMID:9770450
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