User:John S. de Banzie/Sandbox 2
From Proteopedia
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| - | ==Carboxypeptidase A== | + | ==Carboxypeptidase A with "Substrate" Bound== |
| - | <StructureSection load='1zlh' size='400' side='right' caption='Carboxypeptidase A, [[1zlh]]' scene='59/590622/1zlhspacefill/1'> | + | <StructureSection load='1zlh' size='400' side='right' caption='Carboxypeptidase A complexed with an inhibitor that mimics substrate binding, [[1zlh]]' scene='59/590622/1zlhspacefill/1'> |
Carboxypeptidase A catalyses the release of the C-terminal amino acid from a polypeptide chain. The initial image shows carboxypeptidase with a tetrapeptide (green) bound in the active site. | Carboxypeptidase A catalyses the release of the C-terminal amino acid from a polypeptide chain. The initial image shows carboxypeptidase with a tetrapeptide (green) bound in the active site. | ||
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Catalysis involves <scene name='59/590622/1zlhcatalysis/1'>electron withdrawal from the carbonyl of the penultimate residue by the zinc ion and an arginyl residue, and nucleophilic attack on that same group by a glutamyl residue</scene>. | Catalysis involves <scene name='59/590622/1zlhcatalysis/1'>electron withdrawal from the carbonyl of the penultimate residue by the zinc ion and an arginyl residue, and nucleophilic attack on that same group by a glutamyl residue</scene>. | ||
| + | (The tetrapeptide is actually the C-terminus of a protein that inhibits carboxypeptidase A. This portion of the inhibitor mimics the binding of substrate to the active site.) | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 01:45, 13 June 2014
Carboxypeptidase A with "Substrate" Bound
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