User:John S. de Banzie/Sandbox 2

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==RNA Stem and Loop Structure==
==RNA Stem and Loop Structure==
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<StructureSection load='2qh2' size='400' side='right' caption='RNA hairpin loop from human telomerase RNA, [[2qh2]]' scene='59/590622/2qh2stick/1'>
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<StructureSection load='2qh2' size='400' side='right' caption='RNA hairpin loop from human telomerase RNA, [[2qh2]]' scene='59/590622/2qh2stick/3'>
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Intramolecular hydrogen bonding in RNA molecules results in the formation of stem and loop (also known as hairpin loop) structures.
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Intramolecular hydrogen bonding in RNA molecules results in the formation of stem and loop structures (also known as hairpin loops).
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Note that the RNA forms a double stranded <scene name='59/590622/2qh2stickends/1'>antiparallel</scene> right-handed helix with <scene name='59/590622/2qh2spacefill/1'>major and minor grooves</scene>. Note also that the structure is not the same as that of [[DNA]].
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RNA in the stem of a stem and loop structure forms a double stranded <scene name='59/590622/2qh2stickends/1'>antiparallel</scene> right-handed helix with <scene name='59/590622/2qh2spacefill/1'>major and minor grooves</scene>. However this double helix is not the same as that of [[DNA]]. The most obvious difference is in the tilt of the bases, but there are also differences in the diameter and pitch of the helix.
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The RNA shown is 24 nucleotides long. Nucleotides 1 through 8 and 17 through 24 form a stem and nucleotides 9 through 16 form a loop. Note the <scene name='59/590622/2qh2bases/2'>complementary base pairing</scene> in the stem (A: red, C: green, G: orange, T: blue) and the unpaired bases in the loop (white).
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The RNA shown is 24 nucleotides long. Nucleotides 1 through 8 and 17 through 24 form the stem and nucleotides 9 through 16 form the loop. Note the <scene name='59/590622/2qh2bases/2'>complementary base pairing</scene> in the stem (A: red, C: green, G: orange, T: blue) and the unpaired bases in the loop (white).
(The stem and loop structure shown is part of the RNA in human telomerase. Telomerase protects chromosomes by restoring DNA that is lost from the ends during DNA replication. The RNA is used as a template and the enzyme is thus an internally-templated RNA-dependant DNA polymerase.)
(The stem and loop structure shown is part of the RNA in human telomerase. Telomerase protects chromosomes by restoring DNA that is lost from the ends during DNA replication. The RNA is used as a template and the enzyme is thus an internally-templated RNA-dependant DNA polymerase.)

Revision as of 16:18, 13 June 2014

RNA Stem and Loop Structure

RNA hairpin loop from human telomerase RNA, 2qh2

Drag the structure with the mouse to rotate

References

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John S. de Banzie

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