Undecaprenyl pyrophosphate synthase

Function

Undecaprenyl pyrophosphate synthase (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall. Bisphosphonate drugs are UPP inhibitors.

Disease

Relevance

Structural highlights

3D structures of undecaprenyl pyrophosphate synthase

Updated on 15-June-2014

1f75 – UPP (mutant) – Micrococcus luteus

3qas – EcUPP – Escherichia coli
1jp3 – EcUPP (mutant)
2d2r – HpUPP (mutant) – Helicobacter pylori

UPP complexes

1ueh – EcUPP + Mg + SO4 + triton

1v7u – EcUPP + FPP
1x06 – EcUPP + Mg + FPP analog + IPP
1x08 – EcUPP (mutant) + Mg + FPP analog + IPP
1x07 – EcUPP + Mg + IPP
1x09 – EcUPP (mutant) + Mg + IPP
2e98, 2e99, 2e9a, 2e9c, 2e9d, 3th8, 3sgt, 3sgv, 3sgx, 3sh0, 4h2j, 4h2m, 4h2o, 4h38, 4h3c, 4h3a, 4h8e – EcUPP + bisphosphonate
2dtn – HpUPP + pyrophosphate
3ugs - UPP + FPP analog – Campylobacter jejuni

References