Squalene-hopene cyclase

Function

Squalene-hopene cyclase (SHC) catalyzes the conversion of acyclic squalene into the pentacyclic hopene and hopanol in prokaryotes. The reaction which SHC cactalyzes involves the breaking or forming of 13 covalent bonds, the formation of 9 chiral centers and the formation of 5 rings in a single step.

Disease

Relevance

The hopenoids condense lipid membranes and reduce their permeability.

Structural highlights

3D structures of squalene-hopene cyclase

Updated on 16-June-{{REVISIONYEAR}

1sqc – AaSHC – Alicyclobacillus acidocaldarius

2sqc, 3sqc – AaSHC (mutant)

SHC complexes

1gsz – AaSHC + drug

1h35, 1h36, 1h37, 1h39, 1h3a, 1h3b, 1h3c, 1o6h, 1o6q, 1o6r, 1o79 – AaSHC + inhibitor
1ump – AaSHC + 2-azasqualene

References