4mg2

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{{STRUCTURE_4mg2| PDB=4mg2 | SCENE= }}
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==ALKBH2 F102A cross-linked to undamaged dsDNA==
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===ALKBH2 F102A cross-linked to undamaged dsDNA===
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<StructureSection load='4mg2' size='340' side='right' caption='[[4mg2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4mg2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MG2 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/ALKB2_HUMAN ALKB2_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.<ref>PMID:12486230</ref> <ref>PMID:12594517</ref> <ref>PMID:16174769</ref> <ref>PMID:18519673</ref> <ref>PMID:18432238</ref>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2YR:2-DEOXY-N-(2-SULFANYLETHYL)CYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>2YR</scene></td></tr>
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==About this Structure==
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALKBH2, ABH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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[[4mg2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MG2 OCA].
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_oxidative_demethylase DNA oxidative demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.33 1.14.11.33] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mg2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mg2 RCSB], [http://www.ebi.ac.uk/pdbsum/4mg2 PDBsum]</span></td></tr>
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==Reference==
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<table>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: DNA oxidative demethylase]]
[[Category: DNA oxidative demethylase]]
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[[Category: Human]]
[[Category: Chen, B.]]
[[Category: Chen, B.]]
[[Category: Gan, J.]]
[[Category: Gan, J.]]

Revision as of 05:14, 18 June 2014

ALKBH2 F102A cross-linked to undamaged dsDNA

4mg2, resolution 2.30Å

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