4akd

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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Mannose-binding lectin from champedak (Artocarpus integer) is a homotetramer with a single-monomer molecular weight of 16 800 Da. Previous work has shown it to bind IgE and IgM, as well as being a mitogen of T cells in humans. Champedak mannose-binding lectin has successfully been used to detect altered glycosylation states of serum proteins. The protein was crystallized at 293 K in space group P2(1)2(1)2(1) (unit-cell parameters a = 76.89, b = 86.22, c = 95.37 A) and the crystals diffracted to 2.0 A resolution.
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Galactose-binding and mannose-binding lectins from the champedak fruit, which is native to South-east Asia, exhibit useful potential clinical applications. The specificity of the two lectins for their respective ligands allows the detection of potential cancer biomarkers and monitoring of the glycosylated state of proteins in human serum and/or urine. To fully understand and expand the use of these natural proteins, their complete sequences and crystal structures are presented here, together with details of sugar binding.
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Crystallization and initial X-ray diffraction analysis of a mannose-binding lectin from champedak.,Gabrielsen M, Abdul-Rahman PS, Isaacs NW, Hashim OH, Cogdell RJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt 5):592-4. doi:, 10.1107/S1744309110011760. Epub 2010 Apr 30. PMID:20445267<ref>PMID:20445267</ref>
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Structures and binding specificity of galactose- and mannose-binding lectins from champedak: differences from jackfruit lectins.,Gabrielsen M, Abdul-Rahman PS, Othman S, Hashim OH, Cogdell RJ Acta Crystallogr F Struct Biol Commun. 2014 Jun;70(Pt 6):709-16. doi:, 10.1107/S2053230X14008966. Epub 2014 May 24. PMID:24915077<ref>PMID:24915077</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

Revision as of 05:25, 18 June 2014

High resolution structure of Mannose Binding lectin from Champedak (CMB)

4akd, resolution 2.10Å

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